ArticleDysphagia2009
The effects of aging on hypoglossal motoneurons in rats.
Article in Dysphagia, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- The evidence for old age motor neuron death: A scoping review.Physiological reports · 2026Article
- Review
- Tongue blade neuromuscular junction defects in old F344 rats.Respiratory physiology & neurobiology · 2026Article
- Structural and mitochondrial dendritic degenerations in old hypoglossal motor neurons.GeroScience · 2026Article
- Dendritic alterations precede age-related dysphagia and nucleus ambiguus motor neuron death.The Journal of physiology · 2025Article
- Sarcopenia of the longitudinal tongue muscles in rats.Respiratory physiology & neurobiology · 2024Article
- Tongue muscle contractile, fatigue, and fiber type properties in rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Human motor unit characteristics of the superior trapezius muscle with age-related comparisons.Journal of neurophysiology · 2019Article
- Tongue Force Training Induces Plasticity of the Lingual Motor Cortex in Young Adult and Aged Rats.Frontiers in neuroscience · 2019Article
- Rehabilitation Nutrition for Iatrogenic Sarcopenia and Sarcopenic Dysphagia.The journal of nutrition, health & aging · 2019Article
- Phrenic motor neuron loss in aged rats.Journal of neurophysiology · 2018Article
- Effect of Gender on Chronic Intermittent HypoxicFrontiers in physiology · 2018Article
- In Vivo Evaluation of the Mechanical and Viscoelastic Properties of the Rat Tongue.Journal of visualized experiments : JoVE · 2017Article
- Absence of morphological and molecular correlates of sarcopenia in the macaque tongue muscle styloglossus.Experimental gerontology · 2016Article
- Intrinsic excitability differs between murine hypoglossal and spinal motoneurons.Journal of neurophysiology · 2016Article
- Cross-activation and detraining effects of tongue exercise in aged rats.Behavioural brain research · 2016Article
- Differential effects of targeted tongue exercise and treadmill running on aging tongue muscle structure and contractile properties.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Tongue thickness relates to nutritional status in the elderly.Dysphagia · 2012Article
- Effect of aging on ultrasonic vocalizations and laryngeal sensorimotor neurons in rats.Experimental brain research · 2012Article
- The effect of tongue exercise on serotonergic input to the hypoglossal nucleus in young and old rats.Journal of speech, language, and hearing research : JSLHR · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Aging can result in a loss of neuronal cell bodies and a decrease in neuronal size in some regions of the brain and spinal cord. Motoneuron loss in the spinal cord is thought to contribute to the progressive decline in muscle mass and strength that occurs with age (sarcopenia). Swallowing disorders represent a large clinical problem in elderly persons; however, age-related alterations in cranial motoneurons that innervate muscles involved in swallowing have been understudied. We aimed to determine if age-related alterations occurred in the hypoglossal nucleus in the brainstem. If present, these changes might help explain alterations at the neuromuscular junction and changes in the contractile properties of tongue muscle that have been reported in older rats. We hypothesized that with increasing age there would be a loss of motoneurons and a reduction in neuronal size and the number of primary dendrites associated with each hypoglossal motoneuron. Neurons in the hypoglossal nucleus were visualized with the neuronal marker NeuN in young (9-10 months), middle-aged (24-25 months), and old (32-33 months) male F344/BN rats. Hypoglossal motoneurons were retrograde-labeled with injections of Cholera Toxin beta into the genioglossus muscle of the tongue and visualized using immunocytochemistry. Results indicated that the number of primary dendrites of hypoglossal motoneurons decreased significantly with age, while no age-associated changes were found in the number or size of hypoglossal motoneurons. Loss of primary dendrites could reduce the number of synaptic inputs and thereby impair function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.