ArticleMammalian genome : official journal of the International Mammalian Genome Society2008
Establishment of "The Gene Mine": a resource for rapid identification of complex trait genes.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed.
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- Loss of LAMP5 interneurons drives neuronal network dysfunction in Alzheimer's disease.Acta neuropathologica · 2022Article
- Genetic diversity of collaborative cross mice enables identification of novel rift valley fever virus encephalitis model.PLoS pathogens · 2022Article
- A diversity outbred F1 mouse model identifies host-intrinsic genetic regulators of response to immune checkpoint inhibitors.Oncoimmunology · 2022Article
- Progenitor translatome changes coordinated by Tsc1 increase perception of Wnt signals to end nephrogenesis.Nature communications · 2021Article
- Novel spontaneous myelodysplastic syndrome mouse model.Animal models and experimental medicine · 2021Article
- Genetic Regulation of Immunoglobulin G Glycosylation.Experientia supplementum (2012) · 2021Article
- How to Better Understand the Influence of Host Genetics on Developing an Effective Immune Response to Thoracic Cancers.Frontiers in oncology · 2021Review
- E2f8 and Dlg2 genes have independent effects on impaired insulin secretion associated with hyperglycaemia.Diabetologia · 2020Article
- Diverse CD8 T Cell Responses to Viral Infection Revealed by the Collaborative Cross.Cell reports · 2020Article
- A Loss-of-Function Mutation in the Integrin Alpha L (Infection and immunity · 2019Article
- High-Diversity Mouse Populations for Complex Traits.Trends in genetics : TIG · 2019Review
- Whole Genome Sequencing and Progress Toward Full Inbreeding of the Mouse Collaborative Cross Population.G3 (Bethesda, Md.) · 2019Article
- Accelerating cancer without mutations.eLife · 2019Article
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- Advanced Genetic Approaches in Discovery and Characterization of Genes Involved With Osteoporosis in Mouse and Human.Frontiers in genetics · 2019Review
- Variable outcomes of human heart attack recapitulated in genetically diverse mice.NPJ Regenerative medicine · 2019Article
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3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Identification of genes underlying complex traits presents a challenge to which geneticists have responded with many diverse approaches. A common feature of these approaches is that different research groups must, on a case-by-case basis, replicate similar efforts in recruitment, genetic characterization, and analyses. To avoid this expensive "churning," an alternative approach has been proposed: production of an experimental genetic reference population, the Collaborative Cross, in which both genetic diversity and mapping power are maximized. Since this population consists of inbred mouse strains, further advantages are that it is essentially infinitely reproducible; genetic characterization needs to be performed only once; and the founder strains' genomes have been or will be sequenced, allowing imputation of allele sequences of all members of the reference population. Here we describe the establishment of such a genetic reference population, which we dub "The Gene Mine." Over 1000 genetically distinct lines have been established, descended from eight diverse founder strains. Preliminary phenotypic ascertainment of these strains indicates unexpected variability arising from independent assortment of genetic variants. The Gene Mine will be a powerful resource for characterization of essentially any mouse phenotype that has a genetic basis.
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