ArticleParasitology research2008
Alteration of the expression profiles of acidic mucin, sialytransferase, and sulfotransferases in the intestinal epithelium of rats infected with the nematode Nippostrongylus brasiliensis.
Article in Parasitology research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Cross-kingdom dialogs in the gut: Integrating bacterial pathogens, helminths, and microbiota interactions for immune homeostasis.PLoS pathogens · 2025Review
- Goblet cell metaplasia and mucin alterations in biliary epithelial cells duringVeterinary world · 2025Article
- A Small Intestinal Helminth Infection Alters Colonic Mucus and Shapes the Colonic Mucus Microbiome.International journal of molecular sciences · 2024Article
- Protein profile of extracellular vesicles derived from adult Parascaris spp.Parasites & vectors · 2024Article
- Identification and preliminary characterization of Hc-clec-160, a novel C-type lectin domain-containing gene of the strongylid nematode Haemonchus contortus.Parasites & vectors · 2018Article
- A sticky end for gastrointestinal helminths; the role of the mucus barrier.Parasite immunology · 2018Review
- CouldInfectious agents and cancer · 2018Article
- Immune-driven alterations in mucin sulphation is an important mediator of Trichuris muris helminth expulsion.PLoS pathogens · 2017Article
- The immunological characteristics and probiotic function of recombinant Bacillus subtilis spore expressing Clonorchis sinensis cysteine protease.Parasites & vectors · 2016Article
- Gastrointestinal Parasites and the Neural Control of Gut Functions.Frontiers in cellular neuroscience · 2015Review
- Dietary selenium affects intestinal development of Eimeria papillata in mice.Parasitology research · 2014Article
- Mucins as diagnostic and prognostic biomarkers in a fish-parasite model: transcriptional and functional analysis.PloS one · 2013Article
- Mucin-Related Molecular Responses of Bronchial Epithelial Cells in Rats Infected with the Nematode Nippostrongylus brasiliensis.ISRN parasitology · 2013Article
- Helminthic therapy: improving mucosal barrier function.Trends in parasitology · 2012Review
- Mucin-bacterial interactions in the human oral cavity and digestive tract.Gut microbes · 2010Article
- C-type lectins from the nematode parasites Heligmosomoides polygyrus and Nippostrongylus brasiliensis.Parasitology international · 2009Article
- Phylogenetic Analysis of C Type Lectin fromIranian journal of parasitologyArticle
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acidic mucins such as sialomucin and sulfomucin produced by intestinal epithelial cells have been implicated in the protection of the mucosa from pathogens. In the present study, we analyzed the alteration of acidic mucins in the jejunum of euthymic and athymic rats infected with the nematode Nippostrongylus brasiliensis using alcian blue staining and a high iron-diamine method. The numbers of sialomucin+ goblet cells increased markedly 7 and 10 days post-infection and decreased gradually thereafter in euthymic rats, while athymic rats did not show sialomucin+ goblet cell hyperplasia at least until 28 days post-infection, suggesting that sialomucin production might be regulated by thymus-derived T cells. On the other hand, the numbers of sulfomucin+ goblet cells increased markedly 28 days post-infection in both euthymic and athymic rats despite the fact that sulfomucin+ goblet cell numbers in uninfected athymic rats were significantly smaller than in euthymic rats. Real-time polymerase chain reaction studies on the gene transcription levels of O-glycan sulfotransferases Gal3ST1, Gal3ST2, Gal3ST3, and Gal3ST4 in the jejunal epithelium increased gradually toward day 28 post-infection in euthymic and athymic rats. These results suggest that the production of sulfomucin and expression of Gal3STs are inducible by nematode infection without the activation of thymus-derived T cells.
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