ArticlePloS one2008
Genomic diversity within the Enterobacter cloacae complex.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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Who cites it
75 citing papers in PubMed.
- Genome-Resolved Insights Into Phosphate-Solubilizing Bacteria From Wild Rice Rhizosphere Reveal Adaptive Strategies for Phosphorus Cycling Under Acid-Saline Stress in the Mekong Delta, Vietnam.Ecology and evolution · 2026Article
- Genomic characterization ofMicrobiology spectrum · 2026Article
- Genome-Guided Discovery of Vaccine Targets for a Multi-Epitope Construct Against Multidrug-Resistant Enterobacter cloacae.MicrobiologyOpen · 2026Article
- The ESKAPE Challenge: Understanding Resistance and Exploring Alternative Treatments.Antibiotics (Basel, Switzerland) · 2026Review
- Whole-Genome Sequencing Reveals Heterogeneous Resistance Profiles and Selected Mobile Genetic Elements in Ecuadorian ClinicalAntibiotics (Basel, Switzerland) · 2026Article
- Structure of theMicrobiology spectrum · 2026Article
- Ambler class C-type β-lactamases and porin alterations in Enterobacter cloacae complex and Klebsiella aerogenes in the Netherlands, 2012-2023.BMC microbiology · 2026Article
- Antimicrobial resistance and genomic characterization ofFrontiers in microbiology · 2026Article
- Beyond the Spotlight:Antibiotics (Basel, Switzerland) · 2025Review
- Clinical Isolates of Antimicrobial-Resistant Enterobacter Species Can Persist in Human Macrophages Without Replication and Overt Cellular Cytotoxicity.The Journal of infectious diseases · 2025Article
- Genomic analysis of Enterobacter cloacae complex from Southern Thailand reveals insights into multidrug resistance genotypes and genetic diversity.Scientific reports · 2025Article
- Complete genome sequencing of Enterobacter ludwigii strain T977 revealed its great ability for starch degradation of Nicotiana tabacum L. Yunyan 97.BMC microbiology · 2024Article
- ESKAPE pathogens: antimicrobial resistance, epidemiology, clinical impact and therapeutics.Nature reviews. Microbiology · 2024Review
- Comparative Genomics of an Emerging Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2024Article
- High genetic diversity and different type VI secretion systems in Enterobacter species revealed by comparative genomics analysis.BMC microbiology · 2024Article
- Isolation and draft genome sequence ofJournal of genomics · 2024Article
- Advanced vaccinomic, immunoinformatic, and molecular modeling strategies for designing Multi- epitope vaccines against theFrontiers in immunology · 2024Article
- Comprehensive Analysis of Virulence Determinants and Genomic Islands ofAntibiotics (Basel, Switzerland) · 2023Article
- Article
- Species identification, antibiotic resistance, and virulence inFrontiers in microbiology · 2023Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIsolates of the Enterobacter cloacae complex have been increasingly isolated as nosocomial pathogens, but phenotypic identification of the E. cloacae complex is unreliable and irreproducible. Identification of species based on currently available genotyping tools is already superior to phenotypic identification, but the taxonomy of isolates belonging to this complex is cumbersome. METHODOLOGY/PRINCIPAL
findingsThis study shows that multilocus sequence analysis and comparative genomic hybridization based on a mixed genome array is a powerful method for studying species assignment within the E. cloacae complex. The E. cloacae complex is shown to be evolutionarily divided into two clades that are genetically distinct from each other. The younger first clade is genetically more homogenous, contains the Enterobacter hormaechei species and is the most frequently cultured Enterobacter species in hospitals. The second and older clade consists of several (sub)species that are genetically more heterogeneous. Genetic markers were identified that could discriminate between the two clades and cluster 1. CONCLUSIONS/SIGNIFICANCE: Based on genomic differences it is concluded that some previously defined (clonal and heterogenic) (sub)species of the E. cloacae complex have to be redefined because of disagreements with known or proposed nomenclature. However, further improved identification of the redefined species will be possible based on novel markers presented here.
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