ReviewNeuroepidemiology2008
Environmental epidemiology of essential tremor.
Review in Neuroepidemiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- How Common is Essential Tremor? Update on the Worldwide Prevalence of Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2021Pooled it
- Loss-of-function variations in solute carrier family 38 member 6 are associated with essential tremor.Signal transduction and targeted therapy · 2025Article
- Review
- Reduction of neuronal hyperexcitability with modulation of T-type calcium channel or SK channel in essential tremor.International review of neurobiology · 2022Review
- The Essential Tremors: Evolving Concepts of a Family of Diseases.Frontiers in neurology · 2021Review
- Human CYP2D6 in the Brain Is Protective Against Harmine-Induced Neurotoxicity: Evidence from Humanized CYP2D6 Transgenic Mice.Molecular neurobiology · 2020Article
- Genetic Risk Factors for Essential Tremor: A Review.Tremor and other hyperkinetic movements (New York, N.Y.) · 2020Review
- Essential tremor pathology: neurodegeneration and reorganization of neuronal connections.Nature reviews. Neurology · 2020Review
- Cerebellar oscillations driven by synaptic pruning deficits of cerebellar climbing fibers contribute to tremor pathophysiology.Science translational medicine · 2020Article
- Do We Belittle Essential Tremor by Calling It a Syndrome Rather Than a Disease? Yes.Frontiers in neurology · 2020Article
- Blood Harmane (1-Methyl-9H-Pyrido[3,4-b]indole) and Mercury in Essential Tremor: A Population-Based, Environmental Epidemiology Study in the Faroe Islands.Neuroepidemiology · 2020Article
- Prevalence of Essential Tremor in the Faroe Islands: A Population-Based Study.Neuroepidemiology · 2019Article
- Essential tremor then and now: How views of the most common tremor diathesis have changed over time.Parkinsonism & related disorders · 2018Review
- Essential tremor.Handbook of clinical neurology · 2018Review
- The Role of β-Carboline Alkaloids in the Pathogenesis of Essential Tremor.Cerebellum (London, England) · 2016Review
- Article
- Lead exposure and tremor among older men: the VA normative aging study.Environmental health perspectives · 2015Article
- Familial versus Sporadic Essential Tremor: What Patterns Can One Decipher in Age of Onset?Neuroepidemiology · 2015Article
- Blood harmane (1-methyl-9H-pyrido[3,4-b]indole) concentration in dystonia cases vs. controls.Neurotoxicology · 2014Article
- Understanding essential tremor: progress on the biological front.Current neurology and neuroscience reports · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
backgroundEssential tremor (ET) is one of the most common neurological disorders. Despite this, the disease mechanisms and etiology are not well understood. While susceptibility genotypes undoubtedly underlie many ET cases, no ET genes have been identified thus far. As with many other progressive, degenerative neurological disorders, it is likely that environmental factors contribute to the etiology of ET. Environmental epidemiology is the study in specific populations or communities of the effect on human health of physical, biologic and chemical factors in the external environment. The purpose of this article is to review current knowledge with regards to the environmental epidemiology of ET.
resultsAs will be discussed, a series of preliminary case-control studies in recent years has begun to explore several candidate toxins/exposures, including harmane (1-methyl-9H-pyrido[3,4-b]indole), lead and agricultural exposures/pesticides.
conclusionsWhile several initial results are promising, as will be discussed, additional studies are needed to more definitively establish whether these exposures are associated with ET and if they are of etiological importance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.