ArticleGenetics2008
Hitchhiking both ways: effect of two interfering selective sweeps on linked neutral variation.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Article
- Article
- Article
- The classical hitchhiking model with continuous mutational pressure and purifying selection.Ecology and evolution · 2021Article
- Disentangling selection on genetically correlated polygenic traits via whole-genome genealogies.American journal of human genetics · 2021Article
- Polygenic Adaptation in a Population of Finite Size.Entropy (Basel, Switzerland) · 2020Review
- Selective Sweeps Under Dominance and Inbreeding.G3 (Bethesda, Md.) · 2020Article
- The Effects on Neutral Variability of Recurrent Selective Sweeps and Background Selection.Genetics · 2019Article
- Footprints of adaptive evolution revealed by whole Z chromosomes haplotypes in flycatchers.Molecular ecology · 2019Article
- Selective Sweeps.Genetics · 2019Review
- Signatures of natural selection in abiotic stress-responsive genes ofRoyal Society open science · 2018Article
- Diversity of lactase persistence in African milk drinkers.Human genetics · 2015Article
- Obesity susceptibility loci in Qataris, a highly consanguineous Arabian population.Journal of translational medicine · 2015Article
- Adaptive introgression between Anopheles sibling species eliminates a major genomic island but not reproductive isolation.Nature communications · 2014Article
- Robust forward simulations of recurrent hitchhiking.Genetics · 2014Article
- Analysis of the genetic basis of disease in the context of worldwide human relationships and migration.PLoS genetics · 2013Article
- Article
- Molecular signatures identify a candidate target of balancing selection in an arcD-like gene of Staphylococcus epidermidis.Journal of molecular evolution · 2012Article
- Limits to the rate of adaptive substitution in sexual populations.PLoS genetics · 2012Article
- Improved haplotype-based detection of ongoing selective sweeps towards an application in Arabidopsis thaliana.BMC research notes · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neutral polymorphism pattern in the vicinity of a selective sweep can be altered by both stochastic and deterministic factors. Here, we focus on the impact of another selective sweep in the region of influence of a first one. We study the signature left on neutral polymorphism by positive selection at two closely linked loci, when both beneficial mutations reach fixation. We show that, depending on the timing of selective sweeps and on their selection coefficients, the two hitchhiking effects can interfere with each other, leading to less reduction in heterozygosity than a single selective sweep of the same magnitude and more importantly to an excess of intermediate-frequency variants relative to neutrality under some parameter values. This pattern can be sustained and potentially alter the detection of positive selection, including by provoking spurious detection of balancing selection. In situations where positive selection is suspected a priori at several closely linked loci, the polymorphism pattern in the region may also be informative about their selective histories.
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