ArticleGenetics2008
Investigation of mcp1 as a quantitative trait gene for prion disease incubation time in mouse.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Characterisation and prion transmission study in mice with genetic reduction of sporadic Creutzfeldt-Jakob disease risk gene Stx6.Neurobiology of disease · 2024Article
- RETRACTED: Neuroinflammatory Markers: Key Indicators in the Pathology of Neurodegenerative Diseases.Molecules (Basel, Switzerland) · 2022Review
- Neuroinflammation in Prion Disease.International journal of molecular sciences · 2021Review
- Review
- Microglia in prion diseases.The Journal of clinical investigation · 2017Review
- The Role of Microglia in Prion Diseases: A Paradigm of Functional Diversity.Frontiers in aging neuroscience · 2017Review
- Microglial Cx3cr1 knockout reduces prion disease incubation time in mice.BMC neuroscience · 2014Article
- The immunobiology of prion diseases.Nature reviews. Immunology · 2013Review
- Article
- Early cytokine elevation, PrPres deposition, and gliosis in mouse scrapie: no effect on disease by deletion of cytokine genes IL-12p40 and IL-12p35.Journal of virology · 2012Article
- Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Sex effects in mouse prion disease incubation time.PloS one · 2011Article
- The retinoic acid receptor beta (Rarb) region of Mmu14 is associated with prion disease incubation time in mouse.PloS one · 2010Article
- Article
- The metabotropic glutamate receptor subtype 5 mediates sensitivity to the sedative properties of ethanol.Pharmacogenetics and genomics · 2010Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The genetic basis of prion disease incubation time is principally determined by polymorphisms in the prion protein gene, Prnp. However, it is now known that other genetic factors are important. Several quantitative trait loci (QTL) have been identified across the genome including a broad region of linkage on Mmu11. Monocyte chemoattractant protein 1 (MCP-1) maps to this region and has been associated with microglial activation and reduced survival in the ME7 mouse scrapie model of prion disease. We have identified 10 polymorphisms, 3 of which are nonsynonomous, in Mcp1 between "long" (CAST) and "short" (SJL or NZW) incubation-time mouse strains. Crosses between these strains and Mcp1(-/-) mice inoculated with the Chandler/RML mouse scrapie prion strain formed the basis of a quantitative complementation test. In these models loss of Mcp1 did not show an increase in incubation time suggesting that the effects of Mcp1 may be specific to the ME7 prion strain and that Mcp1 does not contribute to the QTL described on Mmu11.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.