ArticleGenetics2008
Second-order moments of segregating sites under variable population size.
Article in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Severe bottleneck of ancient Homo populations: insights from computational modeling and relevant fossil evidence.Molecular biology and evolution · 2026Article
- The TMRCA of general genealogies in populations with deterministically varying size.Theoretical population biology · 2025Article
- Why does the X chromosome lag behind autosomes in GWAS findings?PLoS genetics · 2023Article
- Molecular Evolutionary Rate Predicts Intraspecific Genetic Polymorphism and Species-Specific Selection.Genes · 2022Article
- Neutral genomic signatures of host-parasite coevolution.BMC evolutionary biology · 2019Article
- Computing the joint distribution of the total tree length across loci in populations with variable size.Theoretical population biology · 2017Article
- Decomposing the Site Frequency Spectrum: The Impact of Tree Topology on Neutrality Tests.Genetics · 2017Article
- Coalescence computations for large samples drawn from populations of time-varying sizes.PloS one · 2017Article
- Transition Densities and Sample Frequency Spectra of Diffusion Processes with Selection and Variable Population Size.Genetics · 2015Article
- An analytical framework in the general coalescent tree setting for analyzing polymorphisms created by two mutations.Journal of mathematical biology · 2015Article
- Inferring positive selection in humans from genomic data.Investigative genetics · 2015Article
- General triallelic frequency spectrum under demographic models with variable population size.Genetics · 2014Article
- Statistical properties of the site-frequency spectrum associated with lambda-coalescents.Genetics · 2013Article
- Demographic inference reveals African and European admixture in the North American Drosophila melanogaster population.Genetics · 2013Article
- Coalescent tree imbalance and a simple test for selective sweeps based on microsatellite variation.PLoS computational biology · 2013Article
- Article
- Linkage disequilibrium under recurrent bottlenecks.Genetics · 2012Article
- Identification of X-linked quantitative trait loci affecting cold tolerance in Drosophila melanogaster and fine mapping by selective sweep analysis.Molecular ecology · 2011Article
- Distinguishing positive selection from neutral evolution: boosting the performance of summary statistics.Genetics · 2011Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The identification of genomic regions that have been exposed to positive selection is a major challenge in population genetics. Since selective sweeps are expected to occur during environmental changes or when populations are colonizing a new habitat, statistical tests constructed on the assumption of constant population size are biased by the co-occurrence of population size changes and selection. To delimit this problem and gain better insights into demographic factors, theoretical results regarding the second-order moments of segregating sites, such as the variance of segregating sites, have been derived. Driven by emerging genomewide surveys, which allow the estimation of demographic parameters, a generalized version of Tajima's D has been derived that takes into account a previously estimated demographic scenario to test single loci for traces of selection against the null hypothesis of neutral evolution under variable population size.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.