ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Downregulation of dendritic I(h) in CA1 pyramidal neurons after LTP.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 106 citations in OpenAlex.
- ALDH2-mediated GABA biosynthesis regulates hippocampal LTP and learning adaptability.Nature chemical biology · 2026Article
- Subthreshold Kir and IBiological research · 2026Article
- Interleaved single and bursting spiking resonance in neurons.PLoS computational biology · 2025Article
- Visual activity enhances neuronal excitability in thalamic relay neurons.Science advances · 2025Article
- Distinct Modulation ofeNeuro · 2024Article
- Article
- Intrinsic plasticity of Purkinje cell serves homeostatic regulation of fear memory.Molecular psychiatry · 2024Article
- Cholinergic stimulation stabilizes TRPM4 in the plasma membrane of cortical pyramidal neurons.Frontiers in cell and developmental biology · 2024Article
- Synergies between synaptic and HCN channel plasticity dictates firing rate homeostasis and mutual information transfer in hippocampal model neuron.Frontiers in cellular neuroscience · 2023Article
- Theta patterns of stimulation induce synaptic and intrinsic potentiation in O-LM interneurons.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Microglia-triggered hypoexcitability plasticity of pyramidal neurons in the rat medial prefrontal cortex.Current research in neurobiology · 2022Article
- Identification of HCN1 as a 14-3-3 client.PloS one · 2022Article
- Endocannabinoids Tune Intrinsic Excitability in O-LM Interneurons by Direct Modulation of Postsynaptic Kv7 Channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Review
- Conventional measures of intrinsic excitability are poor estimators of neuronal activity under realistic synaptic inputs.PLoS computational biology · 2021Article
- Memory retention in pyramidal neurons: a unified model of energy-based homo and heterosynaptic plasticity with homeostasis.Cognitive neurodynamics · 2021Article
- Modification of Synaptic-Input Clustering by Intrinsic Excitability Plasticity on Cerebellar Purkinje Cell Dendrites.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Article
- Association of mGluR-Dependent LTD of Excitatory Synapses with Endocannabinoid-Dependent LTD of Inhibitory Synapses Leads to EPSP to Spike Potentiation in CA1 Pyramidal Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperpolarization-activated (h)-channels occupy a central position in dendritic function. Although it has been demonstrated that these channels are upregulated after large depolarizations to reduce dendritic excitation, it is not clear whether they also support other forms of long-term plasticity. We show here that nearly maximal long-term potentiation (LTP) induced by theta-burst pairing produced upregulation in h-channel activity in CA1 pyramidal neurons. In contrast, moderate LTP induced by spike-timing-dependent plasticity or high-frequency stimulation (HFS) downregulated the h-current (I(h)) in the dendrites. After HFS-induced LTP, the h-conductance (G(h)) was reduced without changing its activation. Pharmacological blockade of I(h) had no effect on LTP induction, but occluded EPSP-to-spike potentiation, an input-specific facilitation of dendritic integration. Dynamic-clamp reduction of G(h) locally in the dendrite mimicked the effects of HFS and enhanced synaptic integration in an input-selective way. We conclude that dendritic I(h) is locally downregulated after induction of nonmaximal LTP, thus facilitating integration of the potentiated input.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.