ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Specificity of afferent synapses onto plane-polarized hair cells in the posterior lateral line of the zebrafish.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 117 citations in OpenAlex.
- Electrophysiological Profiling of Exocytosis during Early-Stage Development of the Zebrafish Lateral Line.eNeuro · 2026Article
- Axonal defasciculation is restricted to specific branching points during regeneration of the lateral line nerve in zebrafish.Development (Cambridge, England) · 2026Article
- Whole-body central processing of lateral line inputs encodes flow direction relative to the center-of-mass.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Electrophysiological profiling of exocytosis during early-stage development of the zebrafish lateral line.bioRxiv : the preprint server for biology · 2025Article
- Axonal defasciculation is restricted to specific branching points during regeneration of the lateral line nerve in zebrafish.bioRxiv : the preprint server for biology · 2025Article
- Axon targeting of transcriptionally distinct pioneer neurons is regulated by retinoic acid signaling.Nature communications · 2025Article
- Representation of bulk water flow in the goldfish (Carassius auratus) midbrain.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2025Article
- Presynaptic Nrxn3 is essential for ribbon-synapse maturation in hair cells.Development (Cambridge, England) · 2024Article
- Article
- Age-related changes in the zebrafish and killifish inner ear and lateral line.Scientific reports · 2024Article
- Article
- Presynaptic Nrxn3 is essential for ribbon-synapse assembly in hair cells.bioRxiv : the preprint server for biology · 2024Article
- Neuronal NPR-15 modulates molecular and behavioral immune responses via the amphid sensory neuron-intestinal axis inbioRxiv : the preprint server for biology · 2024Article
- Physiological responses of mechanosensory systems in the head of larval zebrafish (Frontiers in robotics and AI · 2023Article
- Functional and ultrastructural analysis of reafferent mechanosensation in larval zebrafish.Current biology : CB · 2022Article
- Are superficial neuromasts proprioceptors underlying fast copulatory behavior?Frontiers in neural circuits · 2022Article
- Sensory adaptation at ribbon synapses in the zebrafish lateral line.The Journal of physiology · 2021Article
- Functional development and regeneration of hair cells in the zebrafish lateral line.The Journal of physiology · 2021Article
- A neuronal blueprint for directional mechanosensation in larval zebrafish.Current biology : CB · 2021Article
- The Cholinergic Lateral Line Efferent Synapse: Structural, Functional and Molecular Similarities With Those of the Cochlea.Frontiers in cellular neuroscience · 2021Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
The proper wiring of the vertebrate brain represents an extraordinary developmental challenge, requiring billions of neurons to select their appropriate synaptic targets. In view of this complexity, simple vertebrate systems provide necessary models for understanding how synaptic specificity arises. The posterior lateral-line organ of larval zebrafish consists of polarized hair cells organized in discrete clusters known as neuromasts. Here we show that each afferent neuron of the posterior lateral line establishes specific contacts with hair cells of the same hair-bundle polarity. We quantify this specificity by modeling the neuron as a biased selector of hair-cell polarity and find evidence for bias from as early as 2.5 d after fertilization. More than half of the neurons form contacts on multiple neuromasts, but the innervated organs are spatially consecutive and the polarity preference is consistent. Using a novel reagent for correlative electron microscopy, HRP-mCherry, we show that these contacts are indeed afferent synapses bearing vesicle-loaded synaptic ribbons. Moreover, afferent neurons reassume their biased innervation pattern after hair-cell ablation and regeneration. By documenting specificity in the pattern of neuronal connectivity during development and in the context of organ regeneration, these results establish the posterior lateral-line organ as a vertebrate system for the in vivo study of synaptic target selection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.