ArticleBlood2008
Tumor necrosis factor SNP haplotypes are associated with iron deficiency anemia in West African children.
Article in Blood, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Medium cut-off dialyzer improves erythropoiesis stimulating agent resistance in a hepcidin-independent manner in maintenance hemodialysis patients: results from a randomized controlled trial.Scientific reports · 2020Trial
- L-shaped association between dietary iron intake and HPV infection: a cross-sectional analysis based on national health and nutrition examination survey 2005-2016.Frontiers in nutrition · 2025Article
- Iron Metabolism and Inflammatory Mediators in Patients with Renal Dysfunction.International journal of molecular sciences · 2024Review
- Inflammatory markers in geriatric anemia: A study from North India.Journal of family medicine and primary care · 2023Article
- Iron Status and Supplementation during Tuberculosis.Microorganisms · 2023Review
- Analysis of Natural Killer cell functions in patients with hereditary hemochromatosis.EXCLI journal · 2020Article
- Interferon-gamma polymorphisms and risk of iron deficiency and anaemia in Gambian children.Wellcome open research · 2020Article
- Anemia of inflammation.Blood · 2019Review
- How Eliminating Malaria May Also Prevent Iron Deficiency in African Children.Pharmaceuticals (Basel, Switzerland) · 2018Review
- Associations between Common Variants in Iron-Related Genes with Haematological Traits in Populations of African Ancestry.PloS one · 2016Article
- Association between hepatocellular carcinoma and tumor necrosis factor alpha polymorphisms in South Korea.World journal of gastroenterology · 2015Article
- Association of genetic variants with response to iron supplements in pregnancy.Genes & nutrition · 2015Article
- Tumour necrosis factor allele variants and their association with the occurrence and severity of malaria in African children: a longitudinal study.Malaria journal · 2015Article
- The utility of iron chelators in the management of inflammatory disorders.Mediators of inflammation · 2015Review
- DDX39B (BAT1), TNF and IL6 gene polymorphisms and association with clinical outcomes of patients with Plasmodium vivax malaria.Malaria journal · 2014Article
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- Implications of malaria on iron deficiency control strategies.Advances in nutrition (Bethesda, Md.) · 2012Article
- Genetic polymorphisms linked to susceptibility to malaria.Malaria journal · 2011Review
- Iron homeostasis and the inflammatory response.Annual review of nutrition · 2010Review
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9 authors at 4 institutions in 2 countries.
Funding
Abstract
Plasma levels of tumor necrosis factor-alpha (TNF-alpha) are significantly raised in malaria infection and TNF-alpha is thought to inhibit intestinal iron absorption and macrophage iron release. This study investigated putative functional single nucleotide polymorphisms (SNPs) and haplotypes across the major histocompatibility complex (MHC) class III region, including TNF and its immediate neighbors nuclear factor of kappa light polypeptide gene enhancer in B cells (lkappaBL), inhibitor-like 1 and lymphotoxin alpha (LTA), in relation to nutritional iron status and anemia, in a cohort of 780 children across a malaria season. The prevalence of iron deficiency anemia (IDA) increased over the malaria season (P < .001). The TNF(-308) AA genotype was associated with an increased risk of iron deficiency (adjusted OR 8.1; P = .001) and IDA (adjusted OR 5.1; P = .01) at the end of the malaria season. No genotypes were associated with IDA before the malaria season. Thus, TNF appears to be a risk factor for iron deficiency and IDA in children in a malaria-endemic environment and this is likely to be due to a TNF-alpha-induced block in iron absorption.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.