ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2008
Alpha-adrenoceptor blockade modifies neurally induced atrial arrhythmias.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Neurocardiology: translational advancements and potential.The Journal of physiology · 2025Review
- Cardiac Neuroanatomy and Fundamentals of Neurocardiology.Cardiac electrophysiology clinics · 2024Review
- Ganglionic Plexus Ablation: A Step-by-step Guide for Electrophysiologists and Review of Modalities for Neuromodulation for the Management of Atrial Fibrillation.Arrhythmia & electrophysiology review · 2023Review
- Novel Arylpiperazine Derivatives of Salicylamide with αInternational journal of molecular sciences · 2022Article
- The Antiarrhythmic and Hypotensive Effects of S-61 and S-73, the Pyrrolidin-2-one Derivatives with αInternational journal of molecular sciences · 2022Article
- Autonomic imbalance and atrial ectopic activity-a pathophysiological and clinical view.Frontiers in physiology · 2022Review
- Autonomic modulation of ventricular electrical activity: recent developments and clinical implications.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Review
- Review
- Atrial Fibrillation Mechanisms and Implications for Catheter Ablation.Frontiers in physiology · 2018Review
- Significance and clinical characteristics of atrial fibrillation post epicardial access.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2017Article
- Vagal stimulation targets select populations of intrinsic cardiac neurons to control neurally induced atrial fibrillation.American journal of physiology. Heart and circulatory physiology · 2016Article
- Myocardial infarction induces structural and functional remodelling of the intrinsic cardiac nervous system.The Journal of physiology · 2016Article
- Chronic spinal cord stimulation modifies intrinsic cardiac synaptic efficacy in the suppression of atrial fibrillation.Autonomic neuroscience : basic & clinical · 2014Article
- Alpha blockade potentiates CPVT therapy in calsequestrin-mutant mice.Heart rhythm · 2014Article
- Role of the autonomic nervous system in atrial fibrillation: pathophysiology and therapy.Circulation research · 2014Review
- Network interactions within the canine intrinsic cardiac nervous system: implications for reflex control of regional cardiac function.The Journal of physiology · 2013Article
- Activated cranial cervical cord neurons affect left ventricular infarct size and the potential for sudden cardiac death.Autonomic neuroscience : basic & clinical · 2012Article
- Neuromodulation targets intrinsic cardiac neurons to attenuate neuronally mediated atrial arrhythmias.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
- Angiotensin II potentiates adrenergic and muscarinic modulation of guinea pig intracardiac neurons.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
- The cardiac neuronal hierarchy and susceptibility to arrhythmias.Heart rhythm · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Our objective was to determine whether neuronally induced atrial arrhythmias can be modified by alpha-adrenergic receptor blockade. In 30 anesthetized dogs, trains of five electrical stimuli (1 mA; 1 ms) were delivered immediately after the P wave of the ECG to mediastinal nerves associated with the superior vena cava. Regional atrial electrical events were monitored with 191 atrial unipolar electrodes. Mediastinal nerve sites were identified that reproducibly initiated atrial arrhythmias. These sites were then restimulated following 1 h (time control, n = 6), or the intravenous administration of naftopidil (alpha(1)-adrenergic blocker: 0.2 mg/kg, n = 6), yohimbine (alpha(2)-adrenergic blocker: 1 mg/kg, n = 6) or both (n = 8). A ganglionic blocker (hexamethonium: 1 mg/kg) was tested in four dogs. Stimulation of mediastinal nerves sites consistently elicited atrial tachyarrhythmias. Repeat stimulation after 1 h in the time-control group exerted a 19% decrease of the sites still able to induce atrial tachyarrhythmias. Hexamethonium inactivated 78% of the previously active sites. Combined alpha-adrenoceptor blockade inactivated 72% of the previously active sites. Bradycardia responses induced by mediastinal nerve stimulation were blunted by hexamethonium, but not by alpha(1,2)-adrenergic blockade. Naftopidil or yohimbine alone eliminated atrial arrhythmia induction from 31% and 34% of the sites (similar to time control). We conclude that heterogeneous activation of the intrinsic cardiac nervous system results in atrial arrhythmias that involve intrinsic cardiac neuronal alpha-adrenoceptors. In contrast to the global suppression exerted by hexamethonium, we conclude that alpha-adrenoceptor blockade targets intrinsic cardiac local circuit neurons involved in arrhythmia formation and not the flow-through efferent projections of the cardiac nervous system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.