ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2008
Local circuit input to the medullary reticular formation from the rostral nucleus of the solitary tract.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Effects of selective adaptation on coding sugar and salt tastes in mixtures.Chemical senses · 2012Trial
- Spatial and temporal mapping of early alphaherpesvirus invasion routes into the mouse central nervous system.Journal of neurovirology · 2025Article
- Ultrastructure of Rat Rostral Nucleus of the Solitary Tract Terminals in the Parabrachial Nucleus and Medullary Reticular Formation.Frontiers in cellular neuroscience · 2022Article
- Neural Coding of Food Is a Multisensory, Sensorimotor Function.Nutrients · 2021Review
- Autonomic ganglionic injection of α-synuclein fibrils as a model of pure autonomic failure α-synucleinopathy.Nature communications · 2020Article
- Heterogeneity of neuronal responses in the nucleus of the solitary tract suggests sensorimotor integration in the neural code for taste.Journal of neurophysiology · 2019Article
- Response of catecholaminergic neurons in the mouse hindbrain to glucoprivic stimuli is astrocyte dependent.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Interoceptive modulation of neuroendocrine, emotional, and hypophagic responses to stress.Physiology & behavior · 2017Review
- Odor-taste convergence in the nucleus of the solitary tract of the awake freely licking rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- A novel slice preparation to study medullary oromotor and autonomic circuits in vitro.Journal of neuroscience methods · 2014Article
- Adrenoreceptor modulation of oromotor pathways in the rat medulla.Journal of neurophysiology · 2014Article
- Nucleus of the solitary tract in the C57BL/6J mouse: Subnuclear parcellation, chorda tympani nerve projections, and brainstem connections.The Journal of comparative neurology · 2014Article
- Physiological and anatomical properties of intramedullary projection neurons in rat rostral nucleus of the solitary tract.Journal of neurophysiology · 2013Article
- Activation of NPY receptors suppresses excitatory synaptic transmission in a taste-feeding network in the lower brain stem.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Article
- A survey of oral cavity afferents to the rat nucleus tractus solitarii.The Journal of comparative neurology · 2012Article
- Regulation of energy balance and body weight by the brain: a distributed system prone to disruption.The Psychiatric clinics of North America · 2011Article
- Genetic tracing of the gustatory neural pathway originating from Pkd1l3-expressing type III taste cells in circumvallate and foliate papillae.Journal of neurochemistry · 2011Article
- Intrinsic membrane properties of pre-oromotor neurons in the intermediate zone of the medullary reticular formation.Neuroscience · 2010Article
- Suppression of third ventricular NPY-elicited feeding following medullary reticular formation infusions of muscimol.Behavioral neuroscience · 2010Article
- Leptin and the systems neuroscience of meal size control.Frontiers in neuroendocrinology · 2010Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The intermediate reticular formation (IRt) subjacent to the rostral (gustatory) nucleus of the solitary tract (rNST) receives projections from the rNST and appears essential to the expression of taste-elicited ingestion and rejection responses. We used whole cell patch-clamp recording and calcium imaging to characterize responses from an identified population of prehypoglossal neurons in the IRt to electrical stimulation of the rNST in a neonatal rat pup slice preparation. The calcium imaging studies indicated that IRt neurons could be activated by rNST stimulation and that many neurons were under tonic inhibition. Whole cell patch-clamp recording revealed mono- and polysynaptic projections from the rNST to identified prehypoglossal neurons. The projection was primarily excitatory and glutamatergic; however, there were some inhibitory GABAergic projections, and many neurons received excitatory and inhibitory inputs. There was also evidence of disinhibition. Overall, bath application of GABA(A) antagonists increased the amplitude of excitatory currents, and, in several neurons, stimulation of the rNST systematically decreased inhibitory currents. We have hypothesized that the transition from licks to gapes by natural stimuli, such as quinine monohydrochloride, could occur via such disinhibition. We present an updated dynamic model that summarizes the complex synaptic interface between the rNST and the IRt and demonstrates how inhibition could contribute to the transition from ingestion to rejection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.