ArticleJournal of virology2008
AKT1-dependent activation of NF-kappaB by the L protein of parainfluenza virus 5.
Article in Journal of virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- VEGFAngiogenesis · 2026Article
- Regulation of Mumps Virus Replication and Transcription by Kinase RPS6KB1.Journal of virology · 2020Article
- Mechanisms of Maintenance of Foot-and-Mouth Disease Virus Persistence Inferred From Genes Differentially Expressed in Nasopharyngeal Epithelia of Virus Carriers and Non-carriers.Frontiers in veterinary science · 2020Article
- Akt1-mediated CPR cooling protection targets regulators of metabolism, inflammation and contractile function in mouse cardiac arrest.PloS one · 2019Article
- Sendai virus recruits cellular villin to remodel actin cytoskeleton during fusion with hepatocytes.Molecular biology of the cell · 2017Article
- Mumps Virus Nucleoprotein Enhances Phosphorylation of the Phosphoprotein by Polo-Like Kinase 1.Journal of virology · 2016Article
- Inferring Infection Patterns Based on a Connectivity Map of Host Transcriptional Responses.Scientific reports · 2015Article
- Anticancer/antiviral agent Akt inhibitor-IV massively accumulates in mitochondria and potently disrupts cellular bioenergetics.ACS chemical biology · 2015Article
- Roles of serine and threonine residues of mumps virus P protein in viral transcription and replication.Journal of virology · 2014Article
- The L gene of J paramyxovirus plays a critical role in viral pathogenesis.Journal of virology · 2013Article
- Kinase AKT controls innate immune cell development and function.Immunology · 2013Review
- Article
- Synthesis and biological evaluation of analogues of AKT (protein kinase B) inhibitor-IV.Journal of medicinal chemistry · 2011Article
- Activation of IFN-β expression by a viral mRNA through RNase L and MDA5.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Dominant inhibition of Akt/protein kinase B signaling by the matrix protein of a negative-strand RNA virus.Journal of virology · 2011Article
- Potent host-directed small-molecule inhibitors of myxovirus RNA-dependent RNA-polymerases.PloS one · 2011Article
- Reciprocal regulation of AKT and MAP kinase dictates virus-host cell fusion.Journal of virology · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Innate immunity plays a critical role in the control of viral infections. The induction of innate immune responses requires activation of transcription factors. In particular, NF-kappaB plays an essential role in activating the expression of cytokines involved in innate immunity such as beta interferon (IFN-beta) and interleukin-6 (IL-6). However, the mechanisms by which viruses activate NF-kappaB are poorly defined. Infection by parainfluenza virus 5 (PIV5), a prototypical member of the Paramyxoviridae family of Mononegavirales, has been shown to activate the expression of IFN-beta and IL-6. To examine how PIV5 induces this expression, we have examined the activation of NF-kappaB by PIV5 proteins. We have found that expression of PIV5 L protein alone is sufficient to activate NF-kappaB. The L protein of PIV5, the catalytic component of the viral RNA-dependent RNA polymerase, contains six domains that are conserved among all negative-stranded nonsegmented RNA viruses. We have mapped the region that activates NF-kappaB to the second domain, which is thought to be involved in RNA synthesis. The activation of NF-kappaB by L requires AKT1, a serine/threonine kinase, since AKT1 small interfering RNA, an AKT inhibitor as well as a dominant-negative mutant of AKT1, blocks this activation. Furthermore, we have found that L interacts with AKT1 and enhances its phosphorylation. We speculate that L may encode AKT1 kinase activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.