ArticleJournal of virology2008
Hidden virulence determinants in a viral quasispecies in vivo.
Article in Journal of virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
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- Ribavirin as a curative and prophylactic agent against foot and mouth disease virus infection in C57BL/6 suckling and adult mice model.Virusdisease · 2021Article
- Composition and Dynamics of H1N1 and H7N9 Influenza A Virus Quasispecies in a Co-infected Patient Analyzed by Single Molecule Sequencing Technology.Frontiers in genetics · 2021Article
- They are what you eat: Shaping of viral populations through nutrition and consequences for virulence.PLoS pathogens · 2020Review
- National Epidemiology and Evolutionary History of Four Hand, Foot and Mouth Disease-Related Enteroviruses in China from 2008 to 2016.Virologica Sinica · 2020Article
- Engineering Responses to Amino Acid Substitutions in the VP0- and VP3-Coding Regions of PanAsia-1 Strains of Foot-and-Mouth Disease Virus Serotype O.Journal of virology · 2019Article
- Changes in the EV-A71 Genome through Recombination and Spontaneous Mutations: Impact on Virulence.Viruses · 2018Review
- Quasispecies and virus.European biophysics journal : EBJ · 2018Review
- Within host RNA virus persistence: mechanisms and consequences.Current opinion in virology · 2017Review
- Involvement of a joker mutation in a polymerase-independent lethal mutagenesis escape mechanism.Virology · 2016Article
- Deep sequencing analysis of viral infection and evolution allows rapid and detailed characterization of viral mutant spectrum.Bioinformatics (Oxford, England) · 2015Article
- Laboratory animal models to study foot-and-mouth disease: a review with emphasis on natural and vaccine-induced immunity.The Journal of general virology · 2014Review
- A study of the virulence in mice of high copying fidelity variants of human enterovirus 71.Virus research · 2013Article
- Identification of new Potato virus Y (PVY) molecular determinants for the induction of vein necrosis in tobacco.Molecular plant pathology · 2012Article
- Competition-colonization trade-off promotes coexistence of low-virulence viral strains.Journal of the Royal Society, Interface · 2012Article
- Viral population dynamics and virulence thresholds.Current opinion in microbiology · 2012Review
- Viral quasispecies evolution.Microbiology and molecular biology reviews : MMBR · 2012Review
- Mutagenesis-mediated decrease of pathogenicity as a feature of the mutant spectrum of a viral population.PloS one · 2012Article
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The characterization of virulence determinants of pathogenic agents is of utmost relevance for the design of disease control strategies. So far, two classes of virulence determinants have been characterized for viral populations: those imprinted in the nucleotide sequence of some specific genomic regions and those that depend on the complexity of the viral population as such. Here we provide evidence of a virulence determinant that depends neither on a genomic sequence nor on detectable differences in population complexity. Foot-and-mouth disease virus is lethal for C57BL/6 mice showing the highest viral load in pancreas. Virus isolated from pancreas after one passage in mice showed an attenuated phenotype, with no lethality even at the highest dose tested. By contrast, virus from sera of the same mice displayed a virulence similar to that of the parental wild-type clone and virus isolated from spleen displayed an intermediate phenotype. However, viral populations from pancreas, spleen, and serum showed indistinguishable consensus genomic nucleotide sequences and mutant spectrum complexities, as quantified according to the mutation frequencies of both entire genomic nucleotide sequences of biological clones. The results show that the populations with differing virulences cannot be distinguished either by the consensus sequence or by the average complexity of the mutant spectrum. Differential harvesting of virus generated by cell transfection of RNA from serum and pancreas failed to reveal genetic differences between subpopulations endowed with differing virulences. In addition to providing evidence of hidden virulence determinants, this study underlines the capacity of a clone of an RNA virus to rapidly diversify phenotypically in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.