ArticleThe Journal of biological chemistry2008
AMP-activated protein kinase contributes to UV- and H2O2-induced apoptosis in human skin keratinocytes.
Article in The Journal of biological chemistry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
52 citing papers in PubMed, 105 citations in OpenAlex.
- Article
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- Blueberry extract attenuates norepinephrine-induced oxidative stress and apoptosis in H9c2 cardiac cells.Molecular and cellular biochemistry · 2022Article
- Article
- Autophagy plays an essential role in ultraviolet radiation-driven skin photoaging.Frontiers in pharmacology · 2022Review
- β-Nicotinamide Mononucleotide (NMN) Administrated by Intraperitoneal Injection Mediates Protection Against UVB-Induced Skin Damage in Mice.Journal of inflammation research · 2021Article
- Phenformin Promotes Keratinocyte Differentiation via the Calcineurin/NFAT Pathway.The Journal of investigative dermatology · 2021Article
- Hypoxia induces senescence of bone marrow mesenchymal stem cells via altered gut microbiota.Nature communications · 2018Article
- Anti-aging pharmacology in cutaneous wound healing: effects of metformin, resveratrol, and rapamycin by local application.Aging cell · 2017Article
- Autophagy in UV Damage Response.Photochemistry and photobiology · 2017Review
- AMPKα phosphatase Ppm1E upregulation in human gastric cancer is required for cell proliferation.Oncotarget · 2017Article
- Article
- Endogenous AMPK acts as a detrimental factor in fulminant hepatitis via potentiating JNK-dependent hepatocyte apoptosis.Cell death & disease · 2017Article
- Molecular signaling cascades involved in nonmelanoma skin carcinogenesis.The Biochemical journal · 2016Review
- Oxystressed tumor microenvironment potentiates epithelial to mesenchymal transition and alters cellular bioenergetics towards cancer progression.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Aqueous Oldenlandia diffusa extracts inhibits colorectal cancer cells via activating AMP-activated protein kinase signalings.Oncotarget · 2016Article
- Melatonin protects skin keratinocyte from hydrogen peroxide-mediated cell death via the SIRT1 pathway.Oncotarget · 2016Article
- Correlative Light Electron Microscopy: Connecting Synaptic Structure and Function.Frontiers in synaptic neuroscience · 2016Review
- Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine.Journal of hepatology · 2015Article
- Article
Corrections and comments
- Retraction · 2010-05-07Duplication of/in Image ·
- Retracted
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
AMP-activated protein kinase or AMPK is an evolutionarily conserved sensor of cellular energy status, activated by a variety of cellular stresses that deplete ATP. However, the possible involvement of AMPK in UV- and H(2)O(2)-induced oxidative stresses that lead to skin aging or skin cancer has not been fully studied. We demonstrated for the first time that UV and H(2)O(2) induce AMPK activation (Thr(172) phosphorylation) in cultured human skin keratinocytes. UV and H(2)O(2) also phosphorylate LKB1, an upstream signal of AMPK, in an epidermal growth factor receptor-dependent manner. Using compound C, a specific inhibitor of AMPK and AMPK-specific small interfering RNA knockdown as well as AMPK activator, we found that AMPK serves as a positive regulator for p38 and p53 (Ser(15)) phosphorylation induced by UV radiation and H(2)O(2) treatment. We also observed that AMPK serves as a negative feedback signal against UV-induced mTOR (mammalian target of rapamycin) activation in a TSC2-dependent manner. Inhibiting mTOR and positively regulating p53 and p38 might contribute to the pro-apoptotic effect of AMPK on UV- or H(2)O(2)-treated cells. Furthermore, activation of AMPK also phosphorylates acetyl-CoA carboxylase or ACC, the pivotal enzyme of fatty acid synthesis, and PFK2, the key protein of glycolysis in UV-radiated cells. Collectively, we conclude that AMPK contributes to UV- and H(2)O(2)-induced apoptosis via multiple mechanisms in human skin keratinocytes and AMPK plays important roles in UV-induced signal transduction ultimately leading to skin photoaging and even skin cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.