Evidence map›Paper›PMID 18715829›Full record

ArticleTrends in parasitology2008

What happens when Trypanosoma brucei leaves Africa.

Robert E Jensen, Larry Simpson, Paul T Englund

Abstract read
In one paragraph

Article in Trends in parasitology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Molecular Characterization and Prevalence ofPathogens (Basel, Switzerland) · 2026
    Article
  2. RNA Polymerase 1 inhibitors against African trypanosomesAntimicrobial agents and chemotherapy · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. MonomorphicMicrobial genomics · 2021
    Article
  10. Article
  11. Article
  12. The Trypanosomal Transferrin Receptor of Trypanosoma Brucei-A Review.Tropical medicine and infectious disease · 2019
    Review
  13. Article
  14. Article
  15. Biology of Trypanosoma (Trypanozoon) evansi in experimental heterologous mammalian hosts.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2016
    Article
  16. Article
  17. Article
  18. A passion for parasites.The Journal of biological chemistry · 2014
    Article
  19. Single point mutations in ATP synthase compensate for mitochondrial genome loss in trypanosomes.Proceedings of the National Academy of Sciences of the United States of America · 2013
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Robert E JensenDepartment of Cell Biology, Johns Hopkins Medical School, Baltimore, MD 21205, USA.
Larry Simpson
Paul T Englund

Funding

STRUCTURE AND SYNTHESIS OF DNAR01AI058613 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JENSEN, ROBERT E · 2004 to 2013
$7.4M
FUNCTION OF THE KINETOPLAST IN THE HEMOFLAGELLATESR01AI009102 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SIMPSON, LARRY · 1985 to 2013
$7.0M
MITOCHONDRIAL DYNAMICS-MORPHOLOGY/DIVISION/SEGREGATIONR01GM054021 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI JENSEN, ROBERT E · 1996 to 2008
$2.7M
CHITOSOMES AND REGULATED SECRETION IN S CEREVISIAEF32AI009102 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI ZIMAN, MICHAEL · 1994 to 1996
–
FUNCTION OF THE KINETOPLAST IN THE HEMOFLAGELLATESR37AI009102 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SIMPSON, LARRY · 1990 to 1999
–
NIAID NIH HHS AI058613NIAID NIH HHS AI 09102NIAID NIH HHS F32 AI009102NIAID NIH HHS R01 AI009102NIAID NIH HHS R01 AI058613NIAID NIH HHS R37 AI009102NIGMS NIH HHS GM054021NIGMS NIH HHS R01 GM054021
6 · The paper itself

Abstract

Julius Lukes and co-workers evaluated the evolutionary origin of Trypanosoma equiperdum and Trypanosoma evansi, parasites that cause horse and camel diseases. Although similar to T. brucei, the sleeping-sickness parasite, these trypanosomes do not cycle through the tsetse fly and have been able to spread beyond Africa. Transmission occurs sexually, or via blood-sucking flies or vampire bats. They concluded that these parasites, which resemble yeast petite mutants, are T. brucei sub-species, which have evolved recently through changes in mitochondrial DNA.

Indexed as

Adaptation, PhysiologicalAnimalsDNA, KinetoplastDNA, MitochondrialGenes, ProtozoanMembrane Potential, MitochondrialMutationTrypanosoma brucei bruceiDNA, KinetoplastDNA, Mitochondrial

Identifiers

PMID18715829
PMCPMC2725760

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.