Evidence map›Paper›PMID 18715802›Full record

ReviewSeminars in immunology2009

Regulation of CD8(+) T cell functions by RARgamma.

Claire Gordy, Ivan Dzhagalov, You-Wen He

Open access · greenAbstract readReview
In one paragraph

Review in Seminars in immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Targeting the Retinoic Acid Pathway to Eradicate Cancer Stem Cells.International journal of molecular sciences · 2023
    Review
  7. Article
  8. Article
  9. Article
  10. Detection of retinoid receptors in non-neoplastic canine lymph nodes and in lymphoma.The Canadian veterinary journal = La revue veterinaire canadienne · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Claire GordyDepartment of Immunology, Duke University Medical Center, Durham, NC 27710, United States.
Ivan Dzhagalov
You-Wen He
Duke Medical Center · USDuke University Hospital · US

Funding

Regulation of thymocyte maturation and mature T lymphocyte homeostasis by c-FLIPR01AI073947 · NIAID · DUKE UNIVERSITY · PI HE, YOU-WEN · 2008 to 2012
$1.9M
BcI-2 family in T lymphocyte homeostasisR01AI074754 · NIAID · DUKE UNIVERSITY · PI HE, YOU-WEN · 2009 to 2013
$1.9M
ORPHAN NUCLEAR RORgammat IN THYMOCYTE DIFFERENTIATIONR01CA092123 · NCI · DUKE UNIVERSITY · PI HE, YOU-WEN · 2002 to 2006
$1.5M
NCI NIH HHS R01 CA092123NIAID NIH HHS R01 AI073947NIAID NIH HHS R01 AI074754
6 · The paper itself

Abstract

Retinoic acid plays a key role in the development and function of the immune system; however, the contribution of each of the three retinoic acid receptors (RARs) to the T cell immune response is not yet well understood. Of these receptors, both RARalpha and RARgamma are expressed in T lymphocytes. While possible functional redundancy thus complicates understanding of the role of each receptor in T cells, emerging data suggest that RARalpha and RARgamma function differently in thymocyte development and that RARgamma is required for both primary and secondary CD8(+) T cell immune responses.

Indexed as

AnimalsAntineoplastic AgentsApoptosisCD8-Positive T-LymphocytesGastrointestinal TractHumansReceptors, Retinoic AcidRetinoic Acid Receptor gammaT-Lymphocyte SubsetsTretinoinAntineoplastic AgentsReceptors, Retinoic AcidRetinoic Acid Receptor gammaTretinoin

Identifiers

PMID18715802
PMCPMC2615478
OpenAlexW2060016104

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.