Trial reportDiabetes technology & therapeutics2008
Effects of chromium picolinate on food intake and satiety.
Trial report in Diabetes technology & therapeutics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Chromium picolinate supplementation for overweight or obese adults.The Cochrane database of systematic reviews · 2013Pooled it
- The effect of a cinnamon-, chromium- and magnesium-formulated honey on glycaemic control, weight loss and lipid parameters in type 2 diabetes: an open-label cross-over randomised controlled trial.European journal of nutrition · 2016Trial
- A double-blind, randomized pilot trial of chromium picolinate for binge eating disorder: results of the Binge Eating and Chromium (BEACh) study.Journal of psychosomatic research · 2013Trial
- A pilot study of chromium picolinate for weight loss.Journal of alternative and complementary medicine (New York, N.Y.) · 2010Trial
- Interaction Between Chromium Picolinate Supplementation and Strength Training Modifies Cardiomyocyte Relaxation in Obese Rats.Biomedicines · 2026Article
- Nutritional Approaches and Supplementation in Lipedema Management: A Narrative Review of Current Evidence.Current nutrition reports · 2025Review
- Article
- Dietary supplements for lipedema.Journal of preventive medicine and hygiene · 2022Review
- Overfed but undernourished: recognizing nutritional inadequacies/deficiencies in patients with overweight or obesity.International journal of obesity (2005) · 2019Review
- Subchronic exposure to leachate activates key markers linked with neurological disorder in Wistar male rat.Environmental science and pollution research international · 2015Article
- Dietary chromium supplementation for targeted treatment of diabetes patients with comorbid depression and binge eating.Medical hypotheses · 2015Article
- Article
- Scientific Opinion on Dietary Reference Values for chromium.EFSA journal. European Food Safety Authority · 2014Article
- Brain insulin resistance and deficiency as therapeutic targets in Alzheimer's disease.Current Alzheimer research · 2012Review
- Investigations of botanicals on food intake, satiety, weight loss and oxidative stress: study protocol of a double-blind, placebo-controlled, crossover study.Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine · 2011Article
- Effects of chromium picolinate on vascular reactivity and cardiac ischemia-reperfusion injury in spontaneously hypertensive rats.Pharmacological reports : PRArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundChromium picolinate (CrPic) has been shown to attenuate weight gain, but the mechanism underlying this effect is unknown.
methodsWe assessed the effect of CrPic in modulating food intake in healthy, overweight, adult women who reported craving carbohydrates (Study 1) and performed confirmatory studies in Sprague-Dawley rats (Study 2). Study 1 utilized a double-blind placebo-controlled design and randomly assigned 42 overweight adult women with carbohydrate cravings to receive 1,000 mg of CrPic or placebo for 8 weeks. Food intake at breakfast, lunch, and dinner was directly measured at baseline, week 1, and week 8. For Study 2, Sprague-Dawley rats were fasted for 24 h and subsequently injected intraperitoneally with 0, 1, 10, or 50 microg/kg CrPic. Subsequently, rats were implanted with an indwelling third ventricular cannula. Following recovery, 0, 0.4, 4, or 40 ng of CrPic was injected directly into the brain via the intracerebroventricular cannula, and spontaneous 24-h food intake was measured.
resultsStudy 1 demonstrated that CrPic, as compared to placebo, reduced food intake (P<0.0001), hunger levels (P<0.05), and fat cravings (P<0.0001) and tended to decrease body weight (P=0.08). In study 2, intraperitoneal administration resulted in a subtle decrease in food intake at only the highest dose (P=0.03). However, when administered centrally, CrPic dose-dependently decreased food intake (P<0.05).
conclusionsThese data suggest CrPic has a role in food intake regulation, which may be mediated by a direct effect on the brain.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.