ArticleJournal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research2008
Bioinformatic analysis reveals cRel as a regulator of a subset of interferon-stimulated genes.
Article in Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
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- From mechanisms to therapies: the multifaceted roles of guanylate-binding protein 2 in immunity, cancer, and beyond.Frontiers in immunology · 2025Review
- Transcriptional control of interferon-stimulated genes.The Journal of biological chemistry · 2024Review
- Role of the transcription factor Fli-1 on the CXCL10/CXCR3 Axis.Frontiers in immunology · 2023Article
- ISG15 induction is required during L1-mediated colon cancer progression and metastasis.Oncotarget · 2019Article
- Strand-Specific Dual RNA Sequencing of Bronchial Epithelial Cells Infected with Influenza A/H3N2 Viruses Reveals Splicing of Gene Segment 6 and Novel Host-Virus Interactions.Journal of virology · 2018Article
- IFN-γ extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection.PLoS pathogens · 2017Article
- Unphosphorylated STAT3 regulates the antiproliferative, antiviral, and gene-inducing actions of type I interferons.Biochemical and biophysical research communications · 2017Article
- The Contribution of Immune Infiltrates to Ototoxicity and Cochlear Hair Cell Loss.Frontiers in cellular neuroscience · 2017Review
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- An interferon response gene signature is associated with the therapeutic response of hepatitis C patients.PloS one · 2014Article
- Effective use of latent semantic indexing and computational linguistics in biological and biomedical applications.Frontiers in physiology · 2013Article
- A key role for NF-κB transcription factor c-Rel in T-lymphocyte-differentiation and effector functions.Clinical & developmental immunology · 2012Review
- Latent Semantic Indexing of PubMed abstracts for identification of transcription factor candidates from microarray derived gene sets.BMC bioinformatics · 2011Article
- The differential disease regulome.BMC genomics · 2011Article
- Functional cohesion of gene sets determined by latent semantic indexing of PubMed abstracts.PloS one · 2011Article
- Human cytomegalovirus IE1 protein elicits a type II interferon-like host cell response that depends on activated STAT1 but not interferon-γ.PLoS pathogens · 2011Article
- Murine coronavirus delays expression of a subset of interferon-stimulated genes.Journal of virology · 2010Article
- Systemic lipopolysaccharide protects the brain from ischemic injury by reprogramming the response of the brain to stroke: a critical role for IRF3.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Interferons (IFNs) are critical to the host innate immune response by inducing the expression of a family of early response genes, denoted as IFN-stimulated genes (ISGs). The role of tyrosine phosphorylation of STAT proteins in the transcription activation of ISGs is well-documented. Recent studies have indicated that other transcription factors (TFs) are likely to play a role in regulating ISG expression. Here, we describe a novel integrative approach that combines gene expression profiling, promoter sequence analysis, and literature mining to screen candidate regulatory factors in the IFN signal transduction pathway. Application of this method identified the nuclear factor kappaB (NFkappaB) protein, cRel, as a candidate regulatory factor for a subset of ISGs in mouse embryo fibroblasts. Chromatin immunoprecipitation (ChIP) and real-time PCR assays confirmed that cRel directly binds to the promoters of several ISGs, including Cxcl10, Isg15, Gbp2, Ifit3, and Ifi203, and regulates their expression. Thus, our studies identify cRel as an important TF for ISGs, and validate the approach of using Latent Semantic Indexing (LSI)-based methods to identify regulatory factors from microarray data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.