ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2008
Clinical outcomes of hepatitis C treatment in a prison setting: feasibility and effectiveness for challenging treatment populations.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Pooled it
- [Long-term results of autologous transplantation of limbal epithelium cultivated ex vivo for limbal stem cell deficiency].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2016Trial
- "I got so much on my plate": Understanding care discontinuity for HIV and HCV among formerly incarcerated persons.Health services research · 2023Article
- Interventions Designed to Improve HIV Continuum of Care Outcomes for Persons with HIV in Contact with the Carceral System in the USA.Current HIV/AIDS reports · 2022Review
- Hepatitis C Virus Infection in Persons Who Inject Drugs in the Middle East and North Africa: Intervention Strategies.Viruses · 2021Review
- The impact of unrestricted access to direct-acting antiviral among incarcerated hepatitis C virus-infected patients.Clinical and molecular hepatology · 2021Article
- Prisons: ignore them at our peril.Current opinion in HIV and AIDS · 2019Review
- Barriers and facilitators to hepatitis C (HCV) screening and treatment-a description of prisoners' perspective.Harm reduction journal · 2018Article
- Integrated Models of Care for Individuals with Opioid Use Disorder: How Do We Prevent HIV and HCV?Current HIV/AIDS reports · 2018Review
- A pilot study of rapid hepatitis C virus testing in the Rhode Island Department of Corrections.Journal of public health (Oxford, England) · 2016Article
- Prevention of Hepatitis C by Screening and Treatment in U.S. Prisons.Annals of internal medicine · 2016Article
- Hepatitis C virus infection and prisoners: Epidemiology, outcome and treatment.World journal of hepatology · 2015Review
- Personality disorders do not affect treatment outcomes for chronic HCV infection in Spanish prisoners: the Perseo study.BMC infectious diseases · 2015Observational
- A Budget Impact Analysis of Newly Available Hepatitis C Therapeutics and the Financial Burden on a State Correctional System.Journal of urban health : bulletin of the New York Academy of Medicine · 2015Article
- Survey of US Correctional Institutions for Routine HCV Testing.American journal of public health · 2015Article
- HIV in people reincarcerated in Connecticut prisons and jails: an observational cohort study.The lancet. HIV · 2014Article
- Strategies for hepatitis C testing and linkage to care for vulnerable populations: point-of-care and standard HCV testing in a mobile medical clinic.Journal of community health · 2014Article
- Optimization of human immunodeficiency virus treatment during incarceration: viral suppression at the prison gate.JAMA internal medicine · 2014Article
- Hepatitis C in European prisons: a call for an evidence-informed response.BMC infectious diseases · 2014Review
- A descriptive model of patient readiness, motivators, and hepatitis C treatment uptake among Australian prisoners.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMore than one-third of people in the United States with hepatic C virus (HCV) infection pass through the correctional system annually. Data are lacking on outcomes of treatment with pegylated interferon plus ribavirin (PEG-RBV) in correctional settings.
methodsDuring 2002-2006, we analyzed patients in the Connecticut Department of Correction who received PEG-RBV. We assessed the rates of sustained virological response, hospitalization, and use of medications to treat psychiatric disorders and anemia.
resultsOf 138 treatment-naive patients referred for treatment, 68 (49%) were approved. Overall, sustained virological response occurred in 47.1% of patients (for HCV genotype 1, 43.1%; for HCV genotypes 2 and 3, 58.8%). Only 9 patients (13%) discontinued treatment because of adverse effects. Multiple regression analysis revealed that not achieving a sustained virological response was correlated with HCV genotype 1 infection plus cirrhosis (adjusted odds ratio, 12.9; 95% confidence interval, 1.1-148) and baseline major depression (adjusted odds ratio, 3.4; 95% confidence interval, 1.01-11.6), but not with HIV infection, a baseline HCV RNA level >or=400,000 IU/mL, or black race. Compared with baseline, the rate of prescription of a new mood stabilizer (2.2 vs. 0.8 prescriptions per person-year) or an opioid (1.8 vs. 0.5 prescriptions per person-year) was higher during treatment, whereas there was no change in the rate of prescription of benzodiazepines and antipsychotic medications.
conclusionsThese results support the feasibility and clinical effectiveness of PEG-RBV for the treatment of chronic HCV infection in correctional facilities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.