ArticleJournal of the American Chemical Society2008
Time-resolved dimerization of a PAS-LOV protein measured with photocoupled small angle X-ray scattering.
Article in Journal of the American Chemical Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- How fungi see the world: fungal photoreceptors and their role in the regulation of fungal biology.Microbiology and molecular biology reviews : MMBR · 2025Review
- Structural dynamics of protein-protein association involved in the light-induced transition of Avena sativa LOV2 protein.Nature communications · 2024Article
- Evolving Experimental Techniques for Structure-Based Drug Design.The journal of physical chemistry. B · 2022Review
- Contrast variation SAXS: Sample preparation protocols, experimental procedures, and data analysis.Methods in enzymology · 2022Article
- Arguments for an additional long-lived intermediate in the photocycle of the full-length aureochrome 1c receptor: A time-resolved small-angle X-ray scattering study.Structural dynamics (Melville, N.Y.) · 2019Article
- Physical methods for studying flavoprotein photoreceptors.Methods in enzymology · 2019Article
- Blue-Light Receptors for Optogenetics.Chemical reviews · 2018Review
- t-Distributed Stochastic Neighbor Embedding Method with the Least Information Loss for Macromolecular Simulations.Journal of chemical theory and computation · 2018Article
- Small-angle X-ray scattering study of the kinetics of light-dark transition in a LOV protein.PloS one · 2018Article
- At Light Speed: Advances in Optogenetic Systems for Regulating Cell Signaling and Behavior.Annual review of chemical and biomolecular engineering · 2017Review
- Probing fast ribozyme reactions under biological conditions with rapid quench-flow kinetics.Methods (San Diego, Calif.) · 2017Article
- Revealing Hidden Conformational Space of LOV Protein VIVID Through Rigid Residue Scan Simulations.Scientific reports · 2017Article
- Photoreceptor engineering.Frontiers in molecular biosciences · 2015Review
- LOV-based optogenetic devices: light-driven modules to impart photoregulated control of cellular signaling.Frontiers in molecular biosciences · 2015Review
- Short LOV Proteins in Methylocystis Reveal Insight into LOV Domain Photocycle Mechanisms.PloS one · 2015Article
- Direct observation of cooperative protein structural dynamics of homodimeric hemoglobin from 100 ps to 10 ms with pump-probe X-ray solution scattering.Journal of the American Chemical Society · 2012Article
- High-throughput biological small-angle X-ray scattering with a robotically loaded capillary cell.Journal of applied crystallography · 2012Article
- Spatiotemporal control of gene expression by a light-switchable transgene system.Nature methods · 2012Article
- Structure of a light-activated LOV protein dimer that regulates transcription.Science signaling · 2011Article
- Tripping the light fantastic: blue-light photoreceptors as examples of environmentally modulated protein-protein interactions.Biochemistry · 2011Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Time-resolved small-angle X-ray scattering (SAXS) has been used to probe photoexcitation of the blue-light signal transduction protein Vivid (VVD). Laser excitation of sample in a continuous flow cell enables time-resolved measurement of the initial response of VVD to illumination. Good signal-to-noise is achieved without relying on multiple exposures of the same sample or limiting exposure times to prevent radiation damage. The SAXS data demonstrate that VVD dimerizes within tens of milliseconds of light-state activation. Time-resolved SAXS in a flow cell format is a general method for connecting chemical changes in photoreceptors to conformationally driven output signals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.