ArticlePloS one2008
A resource for transcriptomic analysis in the mouse brain.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- A method to analyze gene expression profiles from hippocampal neurons electrophysiologically recordedFrontiers in neuroscience · 2024Article
- MEF2C and HDAC5 regulateNeuronal signaling · 2020Article
- Nicotinic regulation of experience-dependent plasticity in visual cortex.Journal of physiology, Paris · 2016Review
- Clock genes control cortical critical period timing.Neuron · 2015Article
- Remodeling of retrotransposon elements during epigenetic induction of adult visual cortical plasticity by HDAC inhibitors.Epigenetics & chromatin · 2015Article
- Article
- Trehalose-enhanced isolation of neuronal sub-types from adult mouse brain.BioTechniques · 2012Article
- Single-cell and regional gene expression analysis in Alzheimer's disease.Cellular and molecular neurobiology · 2012Review
- Evolution of vertebrate interferon inducible transmembrane proteins.BMC genomics · 2012Article
- Lynx1, a cholinergic brake, limits plasticity in adult visual cortex.Science (New York, N.Y.) · 2010Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe transcriptome of the cerebral cortex is remarkably homogeneous, with variations being stronger between individuals than between areas. It is thought that due to the presence of many distinct cell types, differences within one cell population will be averaged with the noise from others. Studies of sorted cells expressing the same transgene have shown that cell populations can be distinguished according to their transcriptional profile. METHODOLOGY: We have prepared a low-redundancy set of 16,209 full-length cDNA clones which represents the transcriptome of the mouse visual cortex in its coding and non-coding aspects. Using an independent tag-based approach, CAGE, we confirmed the cortical expression of 72% of the clones. Clones were amplified by PCR and spotted on glass slides, and we interrogated the microarrays with RNA from flow-sorted fluorescent cells from the cerebral cortex of parvalbumin-egfp transgenic mice.
conclusionsWe provide an annotated cDNA clone collection which is particularly suitable for transcriptomic analysis in the mouse brain. Spotting it on microarrays, we compared the transcriptome of EGFP positive and negative cells in a parvalbumin-egfp transgenic background and showed that more than 30% of clones are differentially expressed. Our clone collection will be a useful resource for the study of the transcriptome of single cell types in the cerebral cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.