ArticlePloS one2008
Fast homeostatic plasticity of inhibition via activity-dependent vesicular filling.
Article in PloS one, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- The effect of repetitive transcranial magnetic stimulation on gamma oscillatory activity in schizophrenia.PloS one · 2011Trial
- Neuronal Network Inactivity Potentiates Neuropeptide Release from Mouse Cortical Neurons.eNeuro · 2025Article
- GABAergic dysfunction in postmortem dorsolateral prefrontal cortex: implications for cognitive deficits in schizophrenia and affective disorders.Frontiers in cellular neuroscience · 2024Review
- A neuro-inspired computational model of life-long learning and catastrophic interference, mimicking hippocampus novelty-based dopamine modulation and lateral inhibitory plasticity.Frontiers in computational neuroscience · 2022Article
- Subjective tinnitus: lesion-induced pathological central homeostasis remodeling.Journal of otology · 2021Review
- Brief Sensory Deprivation Triggers Cell Type-Specific Structural and Functional Plasticity in Olfactory Bulb Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Prefrontal cortical alterations of glutamate and GABA neurotransmission in schizophrenia: Insights for rational biomarker development.Biomarkers in neuropsychiatry · 2020Article
- Understanding principles of integration and segregation using whole-brain computational connectomics: implications for neuropsychiatric disorders.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2017Review
- Regional Specificity of GABAergic Regulation of Cross-Modal Plasticity in Mouse Visual Cortex after Unilateral Enucleation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Article
- Rebound potentiation of inhibition in juvenile visual cortex requires vision-induced BDNF expression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Glutamic acid decarboxylase 65: a link between GABAergic synaptic plasticity in the lateral amygdala and conditioned fear generalization.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Article
- How local excitation-inhibition ratio impacts the whole brain dynamics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Targeted disruption of layer 4 during development increases GABAA receptor neurotransmission in the neocortex.Journal of neurophysiology · 2014Article
- REST/NRSF-mediated intrinsic homeostasis protects neuronal networks from hyperexcitability.The EMBO journal · 2013Article
- Stable learning of functional maps in self-organizing spiking neural networks with continuous synaptic plasticity.Frontiers in computational neuroscience · 2013Article
- Inhibitory synaptic plasticity: spike timing-dependence and putative network function.Frontiers in neural circuits · 2013Review
- Activity-dependent regulation of inhibition via GAD67.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- GABA metabolism and transport: effects on synaptic efficacy.Neural plasticity · 2012Review
- GABA expression and regulation by sensory experience in the developing visual system.PloS one · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synaptic activity in the central nervous system undergoes rapid state-dependent changes, requiring constant adaptation of the homeostasis between excitation and inhibition. The underlying mechanisms are, however, largely unclear. Chronic changes in network activity result in enhanced production of the inhibitory transmitter GABA, indicating that presynaptic GABA content is a variable parameter for homeostatic plasticity. Here we tested whether such changes in inhibitory transmitter content do also occur at the fast time scale required to ensure inhibition-excitation-homeostasis in dynamic cortical networks. We found that intense stimulation of afferent fibers in the CA1 region of mouse hippocampal slices yielded a rapid and lasting increase in quantal size of miniature inhibitory postsynaptic currents. This potentiation was mediated by the uptake of GABA and glutamate into presynaptic endings of inhibitory interneurons (the latter serving as precursor for the synthesis of GABA). Thus, enhanced release of inhibitory and excitatory transmitters from active networks leads to enhanced presynaptic GABA content. Thereby, inhibitory efficacy follows local neuronal activity, constituting a negative feedback loop and providing a mechanism for rapid homeostatic scaling in cortical circuits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.