ArticleJournal of immunology (Baltimore, Md. : 1950)2008
B lymphocyte activation by coinfection prevents immune control of friend virus infection.
Article in Journal of immunology (Baltimore, Md. : 1950), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 37 citations in OpenAlex.
- Pathogen growth and virulence dynamics drive the host evolution against coinfections.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- CD4Frontiers in immunology · 2023Article
- Aβ plaques do not protect against HSV-1 infection in a mouse model of familial Alzheimer's disease, and HSV-1 does not induce Aβ pathology in a model of late onset Alzheimer's disease.Brain pathology (Zurich, Switzerland) · 2023Article
- Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity.FEMS microbiology reviews · 2019Review
- A Protective Role for the Lectin CD169/Siglec-1 against a Pathogenic Murine Retrovirus.Cell host & microbe · 2019Article
- Correlates of Follicular Helper Bias in the CD4 T Cell Response to a Retroviral Antigen.Frontiers in immunology · 2018Article
- Type I interferon signaling is required for the APOBEC3/Rfv3-dependent neutralizing antibody response but not innate retrovirus restriction.Retrovirology · 2017Article
- Impaired B cell function during viral infections due to PTEN-mediated inhibition of the PI3K pathway.The Journal of experimental medicine · 2017Article
- Dichotomy between T Cell and B Cell Tolerance to Neonatal Retroviral Infection Permits T Cell Therapy.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Tetherin/BST-2 promotes dendritic cell activation and function during acute retrovirus infection.Scientific reports · 2016Article
- Stepwise B-cell-dependent expansion of T helper clonotypes diversifies the T-cell response.Nature communications · 2016Article
- Friend retrovirus drives cytotoxic effectors through Toll-like receptor 3.Retrovirology · 2014Article
- Article
- Clonotypic composition of the CD4+ T cell response to a vectored retroviral antigen is determined by its speed.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Tetherin promotes the innate and adaptive cell-mediated immune response against retrovirus infection in vivo.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Ribonuclease L is not critical for innate restriction and adaptive immunity against Friend retrovirus infection.Virology · 2013Article
- Humoral immunity in the Friend retrovirus infection model.Immunologic research · 2013Review
- Negative impact of IFN-γ on early host immune responses to retroviral infection.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Negative selection by an endogenous retrovirus promotes a higher-avidity CD4+ T cell response to retroviral infection.PLoS pathogens · 2012Article
- Poliomyelitis in MuLV-infected ICR-SCID mice after injection of basement membrane matrix contaminated with lactate dehydrogenase-elevating virus.Comparative medicine · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Although the adaptive immune response almost invariably fails to completely eliminate retroviral infections, it can exert significant protection from disease and long-term control of viral replication. Friend virus (FV), a mouse retrovirus, causes persistent infection in all strains of mice and erythroleukaemia in susceptible strains, the course of which can be strongly influenced by both genetic and extrinsic factors. In this study we examine the impact of coinfection on the requirements for immune control of FV infection. We show that congenic C57BL/6 mice, in which the introduction of an allele of the Friend virus susceptibility 2 gene provides the potential for FV-induced leukemia development, effectively resist FV infection, and both T cell- and Ab-dependent mechanisms contribute to their resistance. However, we further demonstrate that coinfection with lactate dehydrogenase-elevating virus (LDV) renders these otherwise immunocompetent mice highly susceptible to FV infection and subsequent disease. The presence of LDV delays induction of FV-specific neutralizing Abs and counteracts the protective contribution of adaptive immunity. Importantly, the disease-enhancing effect of LDV coinfection requires the presence of a polyclonal B cell repertoire and is reproduced by direct polyclonal B cell activation. Thus, immune activation by coinfecting pathogens or their products can contribute to the pathogenicity of retroviral infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.