ArticleAmerican journal of physiology. Endocrinology and metabolism2008
Skeletal and cardiac myopathy in HIV-1 transgenic rats.
Article in American journal of physiology. Endocrinology and metabolism, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- A longitudinal characterization of sex-specific somatosensory and spatial memory deficits in HIV Tg26 heterozygous mice.PloS one · 2020Article
- The Proposal of Molecular Mechanisms of Weak Organic Acids Intake-Induced Improvement of Insulin Resistance in Diabetes Mellitus via Elevation of Interstitial Fluid pH.International journal of molecular sciences · 2018Review
- The HIV-1 transgenic rat model of neuroHIV.Brain, behavior, and immunity · 2015Review
- Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1.American journal of physiology. Endocrinology and metabolism · 2014Review
- Strain-dependent differences for suppression of insulin-stimulated glucose uptake in skeletal and cardiac muscle by ethanol.Alcoholism, clinical and experimental research · 2014Article
- Biomedical consequences of alcohol use disorders in the HIV-infected host.Current HIV research · 2014Review
- Chronic alcohol consumption disrupts myocardial protein balance and function in aged, but not adult, female F344 rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Interferon-γ causes cardiac myocyte atrophy via selective degradation of myosin heavy chain in a model of chronic myocarditis.The American journal of pathology · 2012Article
- Human immunodeficiency virus transgenic rats exhibit pulmonary hypertension.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- Chronic alcohol ingestion exacerbates skeletal muscle myopathy in HIV-1 transgenic rats.AIDS research and therapy · 2011Article
- The role and regulation of MAFbx/atrogin-1 and MuRF1 in skeletal muscle atrophy.Pflugers Archiv : European journal of physiology · 2011Review
- Cancer causes cardiac atrophy and autophagy in a sexually dimorphic manner.Cancer research · 2011Article
- Methamphetamine-induced behavioral and physiological effects in adolescent and adult HIV-1 transgenic rats.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2010Article
- Skeletal muscle catabolism in trinitrobenzene sulfonic acid-induced murine colitis.Metabolism: clinical and experimental · 2010Article
- Castration differentially alters basal and leucine-stimulated tissue protein synthesis in skeletal muscle and adipose tissue.American journal of physiology. Endocrinology and metabolism · 2009Article
- Procysteine stimulates expression of key anabolic factors and reduces plantaris atrophy in alcohol-fed rats.Alcoholism, clinical and experimental research · 2009Article
- Altered lipid concentrations of liver, heart and plasma but not brain in HIV-1 transgenic rats.Prostaglandins, leukotrienes, and essential fatty acidsArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The mechanism by which human immunodeficiency virus (HIV)-1 infection in humans leads to the erosion of lean body mass is poorly defined. Therefore, the purpose of the present study was to determine whether transgenic (Tg) rats that constitutively overexpress HIV-1 viral proteins exhibit muscle wasting and to elucidate putative mechanisms. Over 7 mo, Tg rats gained less body weight than pair-fed controls exclusively as a result of a proportional reduction in lean, not fat, mass. Fast- and slow-twitch muscle atrophy in Tg rats did not result from a reduction in the in vivo-determined rate of protein synthesis. In contrast, urinary excretion of 3-methylhistidine, as well as the content of atrogin-1 and the 14-kDa actin fragment, was elevated in gastrocnemius of Tg rats, suggesting increased muscle proteolysis. Similarly, Tg rats had reduced cardiac mass, which was independent of a change in protein synthesis. This decreased cardiac mass was associated with a reduction in stroke volume, but cardiac output was maintained by a compensatory increase in heart rate. The HIV-induced muscle atrophy was associated with increased whole body energy expenditure, which was not due to an elevated body temperature or secondary bacterial infection. Furthermore, the atrophic response could not be attributed to the development of insulin resistance, decreased levels of circulating amino acids, or increased tissue cytokines. However, skeletal muscle and, to a lesser extent, circulating insulin-like growth factor I was reduced in Tg rats. Although hepatic injury was implicated by increased plasma levels of aspartate and alanine aminotransferases, hepatic protein synthesis was not different between control and Tg rats. Hence, HIV-1 Tg rats develop atrophy of cardiac and skeletal muscle, the latter of which results primarily from an increased protein degradation and may be related to the marked reduction in muscle insulin-like growth factor I.
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