ReviewAnesthesia and analgesia2008
Is a new paradigm needed to explain how inhaled anesthetics produce immobility?
Review in Anesthesia and analgesia, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 119 citations in OpenAlex.
- Article
- [Causes and prevention strategies of postoperative nausea and vomiting after orthognathic surgery].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2025Review
- The quantum-classical complexity of consciousness and orchestrated objective reduction.Frontiers in human neuroscience · 2025Article
- A quantum microtubule substrate of consciousness is experimentally supported and solves the binding and epiphenomenalism problems.Neuroscience of consciousness · 2025Article
- Conscious active inference II: Quantum orchestrated objective reduction among intraneuronal microtubules naturally accounts for discrete perceptual cycles.Computational and structural biotechnology journal · 2025Review
- Article
- Review
- Screening for bilayer-active and likely cytotoxic molecules reveals bilayer-mediated regulation of cell function.The Journal of general physiology · 2023Article
- Consciousness, Cognition and the Neuronal Cytoskeleton - A New Paradigm Needed in Neuroscience.Frontiers in molecular neuroscience · 2022Article
- Altered Membrane Mechanics Provides a Receptor-Independent Pathway for Serotonin Action.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Anesthesia-Induced Oxidative Stress: Are There Differences between Intravenous and Inhaled Anesthetics?Oxidative medicine and cellular longevity · 2021Review
- Article
- Antidepressants are modifiers of lipid bilayer properties.The Journal of general physiology · 2019Article
- The actions of volatile anesthetics: a new perspective.Acta crystallographica. Section D, Structural biology · 2018Review
- Intravenous Anesthetic, Propofol Affects Synaptic Responses in Cerebellar Purkinje Cells.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2018Article
- Xenon pressure dependence on the synchronized burst inhibition of rat cortical neuronal network cultured on multi-electrode arrays.IBRO reports · 2017Article
- Anesthetic Alterations of Collective Terahertz Oscillations in Tubulin Correlate with Clinical Potency: Implications for Anesthetic Action and Post-Operative Cognitive Dysfunction.Scientific reports · 2017Article
- Clinical concentrations of chemically diverse general anesthetics minimally affect lipid bilayer properties.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Isoflurane, but Not the Nonimmobilizers F6 and F8, Inhibits Rat Spinal Cord Motor Neuron CaV1 Calcium Currents.Anesthesia and analgesia · 2016Article
- Understanding of anesthesia - Why consciousness is essential for life and not based on genes.Communicative & integrative biology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
A paradox arises from present information concerning the mechanism(s) by which inhaled anesthetics produce immobility in the face of noxious stimulation. Several findings, such as additivity, suggest a common site at which inhaled anesthetics act to produce immobility. However, two decades of focused investigation have not identified a ligand- or voltage-gated channel that alone is sufficient to mediate immobility. Indeed, most putative targets provide minimal or no mediation. For example, opioid, 5-HT3, gamma-aminobutyric acid type A and glutamate receptors, and potassium and calcium channels appear to be irrelevant or play only minor roles. Furthermore, no combination of actions on ligand- or voltage-gated channels seems sufficient. A few plausible targets (e.g., sodium channels) merit further study, but there remains the possibility that immobilization results from a nonspecific mechanism.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.