ArticleProceedings of the National Academy of Sciences of the United States of America2008
TRIM28 mediates primer binding site-targeted silencing of Lys1,2 tRNA-utilizing retroviruses in embryonic cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 62 citations in OpenAlex.
- TRIM37 interacts with TRIM28 to maintain primordial germ cell identity during migration.Cell research · 2026Article
- Review
- Species-specific KRAB-ZFPs function as repressors of retroviruses by targeting PBS regions.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Host T Cell Dedifferentiation Effects Drive HIV-1 Latency Stability.Journal of virology · 2022Article
- Trim28 acts as restriction factor of prototype foamy virus replication by modulating H3K9me3 marks and destabilizing the viral transactivator Tas.Retrovirology · 2021Article
- Review
- Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons.Science advances · 2020Article
- KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage.eLife · 2020Article
- TRIM5α self-assembly and compartmentalization of the HIV-1 viral capsid.Nature communications · 2020Article
- The Lupus Susceptibility Locus Sgp3 Encodes the Suppressor of Endogenous Retrovirus Expression SNERV.Immunity · 2019Article
- Antiviral resistance of stem cells.Current opinion in immunology · 2019Review
- KAP1 regulates endogenous retroviruses in adult human cells and contributes to innate immune control.EMBO reports · 2018Article
- Differentiation-dependent antiviral capacities of amphibian (The Journal of biological chemistry · 2018Article
- Phosphorylation of TRIM28 Enhances the Expression of IFN-β and Proinflammatory Cytokines During HPAIV Infection of Human Lung Epithelial Cells.Frontiers in immunology · 2018Article
- Article
- Transcriptional Silencing of Moloney Murine Leukemia Virus in Human Embryonic Carcinoma Cells.Journal of virology · 2017Article
- Friend or Foe: Epigenetic Regulation of Retrotransposons in Mammalian Oogenesis and Early Development.The Yale journal of biology and medicine · 2016Review
- Transposable Elements and Their KRAB-ZFP Controllers Regulate Gene Expression in Adult Tissues.Developmental cell · 2016Article
- Article
- Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Murine leukemia viruses (MLVs) and related retroelements are potently restricted in embryonic cells by postintegration transcriptional silencing, likely to protect the germ line from insertional mutagenesis. This silencing is in large part attributable to the presence of a nuclear repression complex, which targets a sequence element of the proviral DNA, the repressor-binding site. The repressor-binding site closely overlaps the tRNA primer binding site, a highly conserved sequence essential for virus replication and defining the site of initiation of DNA synthesis during reverse transcription. We have recently demonstrated that the cellular corepressor TRIM28 is recruited to the proline tRNA primer-binding site used by many MLVs and is required to mediate this silencing. Here, we show that TRIM28 is also required for the restriction of retroviruses using a completely distinct tRNA for the priming of their DNA synthesis, namely Lys-1,2 tRNA. These results generalize the role of TRIM28 in retroviral restriction and suggest that this system has evolved to restrict multiple retroviruses.
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