ArticleProceedings. Biological sciences2008
A latitudinal cline in the Chinook salmon (Oncorhynchus tshawytscha) Clock gene: evidence for selection on PolyQ length variants.
Article in Proceedings. Biological sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
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Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 116 citations in OpenAlex.
- Light at night and risk of breast cancer: a systematic review and dose-response meta-analysis.International journal of health geographics · 2021Pooled it
- Pooled it
- Natural Variation in Drosophila melanogaster Clock PolyQ Length: Geographic Gradients and Functional Properties.Molecular ecology · 2026Article
- Convergent latitudinal erosion of circadian systems in a rapidly diversifying order of fishes.PLoS genetics · 2026Article
- Integration of photoperiod and time-restricted feeding on the circadian gene rhythms in juvenile salmon.Scientific reports · 2025Article
- PolyQ Length of the Clock Gene Is Correlated With Pelagic Larval Duration in the Damselfishes (Pomacentridae), but Within a Species Habitat Availability Counts.Ecology and evolution · 2025Article
- Clinal Variation in Short Tandem Repeats Linked to Gene Expression in Sunflower (Biomolecules · 2024Article
- Epigenetics and seasonal timing in animals: a concise review.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Review
- Ecological features of upriver migration in Kitakami River chum salmon and their connection to aerobic thermal performance.Conservation physiology · 2024Article
- Archaic Introgression Shaped Human Circadian Traits.Genome biology and evolution · 2023Article
- Article
- Circadian gene variation in relation to breeding season and latitude in allochronic populations of two pelagic seabird species complexes.Scientific reports · 2023Article
- Article
- The adaptive nature of the plant circadian clock in natural environments.Plant physiology · 2022Article
- Population-specific association of Clock gene polymorphism with annual cycle timing in stonechats.Scientific reports · 2022Article
- Review
- Article
- Compound Dynamics and Combinatorial Patterns of Amino Acid Repeats Encode a System of Evolutionary and Developmental Markers.Genome biology and evolution · 2019Article
- A Variable Polyglutamine Repeat Affects Subcellular Localization and Regulatory Activity of aG3 (Bethesda, Md.) · 2018Article
- Clock gene is associated with individual variation in the activation of reproductive endocrine and behavior of Asian short toed lark.Scientific reports · 2017Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A critical seasonal event for anadromous Chinook salmon (Oncorhynchus tshawytscha) is the time at which adults migrate from the ocean to breed in freshwater. We investigated whether allelic variation at the circadian rhythm genes, OtsClock1a and OtsClock1b, underlies genetic control of migration timing among 42 populations in North America. We identified eight length variants of the functionally important polyglutamine repeat motif (PolyQ) of OtsClock1b while OtsClock1a PolyQ was highly conserved. We found evidence of a latitudinal cline in average allele length and frequency of the two most common OtsClock1b alleles. The shorter 335 bp allele increases in frequency with decreasing latitude while the longer 359 bp allele increases in frequency at higher latitudes. Comparison to 13 microsatellite loci showed that 335 and 359 bp deviate significantly from neutral expectations. Furthermore, a hierarchical gene diversity analysis based on OtsClock1b PolyQ variation revealed that run timing explains 40.9 per cent of the overall genetic variance among populations. By contrast, an analysis based on 13 microsatellite loci showed that run timing explains only 13.2 per cent of the overall genetic variance. Our findings suggest that length polymorphisms in OtsClock1b PolyQ may be maintained by selection and reflect an adaptation to ecological factors correlated with latitude, such as the seasonally changing day length.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.