ArticleClinical and experimental immunology2008
Leishmania surface protein gp63 binds directly to human natural killer cells and inhibits proliferation.
Article in Clinical and experimental immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 60 citations in OpenAlex.
- Development of DNA Aptamers AgainstPharmaceutics · 2026Article
- An overview of host immune responses against Leishmania spp. infections.Human molecular genetics · 2025Review
- Unleashing the immune modulatory potential ofFrontiers in molecular biosciences · 2025Article
- Toxoplasma gondii suppress human cord blood cell differentiation to the NK cell population.Immunity, inflammation and disease · 2024Article
- Th17 Cell and Inflammatory Infiltrate Interactions in Cutaneous Leishmaniasis: Unraveling Immunopathogenic Mechanisms.Immune network · 2024Review
- Immunoinformatics Approach to Design a Multi-Epitope Vaccine against Cutaneous Leishmaniasis.Vaccines · 2023Article
- A cercarial invadolysin interferes with the host immune response and facilitates infection establishment of Schistosoma mansoni.PLoS pathogens · 2023Article
- Review
- Opinion Article: NK Cells in Cutaneous Leishmaniasis: Protection or Damage?Frontiers in immunology · 2022Article
- Insights intoVeterinary sciences · 2021Review
- LmjF.22.0810 fromBiomedicines · 2020Article
- Detection of Metalloproteases and Cysteine Proteases RNA Transcripts ofBioMed research international · 2020Article
- Reconstituting NK Cells After Allogeneic Stem Cell Transplantation Show Impaired Response to the Fungal PathogenFrontiers in immunology · 2020Article
- Review on the Role of Host Immune Response in Protection and Immunopathogenesis during Cutaneous Leishmaniasis Infection.Journal of immunology research · 2020Review
- Cutaneous Leishmaniasis: The Complexity of Host's Effective Immune Response against a Polymorphic Parasitic Disease.Journal of immunology research · 2019Review
- Using proteomics as a powerful tool to develop a vaccine against Mediterranean visceral leishmaniasis.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2018Review
- Monocyte-Derived Signals Activate Human Natural Killer Cells in Response toFrontiers in immunology · 2018Article
- Cytotoxic activity in cutaneous leishmaniasis.Memorias do Instituto Oswaldo Cruz · 2017Review
- CD56 Is a Pathogen Recognition Receptor on Human Natural Killer Cells.Scientific reports · 2017Article
- Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Natural killer (NK) cells contribute to immunity as the first line of defence in numerous infections by early cytokine secretion and cytotoxicity. In Leishmania infection, NK cells contribute with interferon-gamma and may assist in directing the immune response towards T helper type 1, which is essential for successful control of the parasites. Thus, NK cells may play an important role in both resistance and control of the infection. However, during Leishmania infection NK cells show signs of suppression. To explore the reason for this suppression, we exposed naive and interleukin (IL)-2 activated NK cells directly to promastigotes of Leishmania major in vitro. As a rapid consequence of contact between naive NK cells and promastigotes, expression of NK cell receptors show significant changes. We identify one of the major surface molecules of promastigotes, glycoprotein (gp) 63, as an important agent for these suppressive effects by using promastigotes of a gp63ko strain of L. major. Furthermore, proliferation of IL-2-activated purified NK cells is suppressed after exposure to the wild-type but not to gp63ko promastigotes. However, gp63ko L. major induced no NK cell proliferation when NK cells were co-cultured with peripheral blood mononuclear cells populations such as CD14(+) monocytes or T cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.