ReviewSports medicine (Auckland, N.Z.)2008
Heat shock protein 72 response to exercise in humans.
Review in Sports medicine (Auckland, N.Z.), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Meta-Analysis of the Effect of Exercise on Neuropathic Pain Induced by Peripheral Nerve Injury in Rat Models.Frontiers in neurology · 2019Pooled it
- The biphasic activity of autophagy and heat shock protein response in peripheral blood mononuclear cells following acute resistance exercise in resistance-trained males.European journal of applied physiology · 2024Trial
- Effect of repeated post-resistance exercise cold or hot water immersion on in-season inflammatory responses in academy rugby players: a randomised controlled cross-over design.European journal of applied physiology · 2024Trial
- Human monocyte heat shock protein 72 responses to acute hypoxic exercise after 3 days of exercise heat acclimation.BioMed research international · 2015Trial
- Heat Shock Proteins and Exercise in Skeletal Muscle Insulin Resistance: Protective Mechanisms and Therapeutic Potential.International journal of molecular sciences · 2026Review
- Exploring Molecular Pathways in Exercise-Induced Recovery from Traumatic Brain Injury.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- Unveiling the role of exercise in modulating plasma heat shock protein 27 levels: insights for exercise immunology and cardiovascular health.Molecular and cellular biochemistry · 2025Review
- Exercise therapy for knee osteoarthritis pain: how does it work? A study protocol for a randomised controlled trial.BMJ open · 2024Article
- Immunological mechanisms of exercise therapy in dyslipidemia.Frontiers in physiology · 2022Review
- Hepatokines as a Molecular Transducer of Exercise.Journal of clinical medicine · 2021Review
- Individual Responses to Heat Stress: Implications for Hyperthermia and Physical Work Capacity.Frontiers in physiology · 2020Review
- Chaperone-Based Therapeutic Target Innovation: Heat Shock Protein 70 (HSP70) for Type 2 Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Review
- Hepatokines-a novel group of exercise factors.Pflugers Archiv : European journal of physiology · 2019Review
- Cross-Adaptation: Heat and Cold Adaptation to Improve Physiological and Cellular Responses to Hypoxia.Sports medicine (Auckland, N.Z.) · 2017Review
- Short-term intense exercise training reduces stress markers and alters the transcriptional response to exercise in skeletal muscle.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- The effect of passive heating on heat shock protein 70 and interleukin-6: A possible treatment tool for metabolic diseases?Temperature (Austin, Tex.) · 2017Article
- Effects of different fluid replacements on serum HSP70 and lymphocyte DNA damage in college athletes during exercise at high ambient temperatures.Journal of sport and health science · 2016Article
- Distinct Skeletal Muscle Gene Regulation from Active Contraction, Passive Vibration, and Whole Body Heat Stress in Humans.PloS one · 2016Article
- Low-Intensity Pulsed Ultrasound Stimulation Enhances Heat-Shock Protein 90 and Mineralized Nodule Formation in Mouse Calvaria-Derived Osteoblasts.Tissue engineering. Part A · 2015Article
- Limitations to Thermoregulation and Acclimatization Challenge Human Adaptation to Global Warming.International journal of environmental research and public health · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat shock protein (Hsp) 72 is a unique, ubiquitous molecule. In vitro and in vivo animal models have shown that increased Hsp 72 is associated with improved cellular survivability and tolerance to stressors. The primary focus of this article is to review the Hsp 72 protein response to exercise in humans. Various mechanisms regulate post-transcriptional activity and therefore measurement of messenger RNA (mRNA) does not necessarily represent the level of functional Hsp 72. For this reason, this article incorporates only a few studies that assessed Hsp 72 mRNA response to exercise. Although this article focuses on human studies, it also includes some key animal studies to provide insight into the mechanisms of the response of Hsp 72 to stress.Intra- (IC) and extracellular (EC) Hsp 72 have different functions. IC Hsp 72 confers cellular protection from subsequent stressors, while EC Hsp 72 has a whole-body systemic role in antigen presentation and immunity. An acute exercise bout stimulates an increase in both IC and EC Hsp 72. Long-term training and improved fitness increases the rate of availability of IC Hsp 72 in response to stress. Other factors that affect Hsp 72 production include environmental factors, exercise mode, duration and intensity, age, estrogen, and anti-oxidant and glycogen availability. The functions and roles of Hsp 72 also depend on the tissue of origin. This article describes the Hsp 72 response to exercise in relation to the tissue assayed (i.e. skeletal muscle vs lymphocyte) and the origin of the sample (i.e. venous vs arterial serum). Collectively, the reviewed studies reveal exciting and novel research that encourages future investigation in this area.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.