ArticleBreast cancer research and treatment2009
Vitreo-retinal traction and anastrozole use.
Article in Breast cancer research and treatment, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- The effects of systemic aromatase inhibitors on meibomian glands and corneal structure.Eye (London, England) · 2022Observational
- A case report of cystoid macular edema, uveitis and vitreomacular traction in a patient taking Anastrozole.American journal of ophthalmology case reports · 2022Article
- Review of the Literature on Ocular Complications Associated With Aromatase Inhibitor Use.Cureus · 2021Review
- Subepithelial Corneal Deposits Associated with Exemestane.Case reports in ophthalmological medicine · 2020Article
- Ocular side effects of biological agents in oncology: what should the clinician be aware of?OncoTargets and therapy · 2013Review
- Differential effects of the estrogen receptor agonist estradiol on toxicity induced by enzymatically-derived or autoxidation-derived oxysterols in human ARPE-19 cells.Current eye research · 2013Article
- Breast cancer medications and vision: effects of treatments for early-stage disease.Current eye research · 2011Review
- Variability in short-wavelength automated perimetry among peri- or postmenopausal women: a dependence on phyto-oestrogen consumption?Acta ophthalmologica · 2011Article
- Ocular Side Effects of Aromatase Inhibitor Endocrine Therapy in Breast Cancer - A Review.In vivo (Athens, Greece)Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
purposeThis study tested a prediction stemming from the hypothesis that anastrozole users experience heightened vitreo-retinal traction. This hypothesis was based on the knowledge that menopause increases the risk of intraocular tractional events such as posterior vitreous detachments (PVDs).
methodsRetinal thickness was measured for 3 groups of amenorrheic women: (1) anastrozole users and (2) tamoxifen users undergoing adjuvant therapy for early-stage breast cancer, and (3) control subjects not using hormonal medication. Foveal shape indices were derived for subjects without PVDs.
resultsFor anastrozole users, the distance to the temporal side of the fovea became less than the distance to the nasal side at a sufficient height above the foveal base. This effect did not exist for control subjects; the between-group difference was appreciable. Results concerning tamoxifen users were inconclusive.
conclusionsThe foveas of women using anastrozole appear to be subjected to more tractional force than are the foveas of women not using any hormonal medication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.