ArticleJournal of neurology2008
Acute stroke unit care and early neurological deterioration in ischemic stroke.
Article in Journal of neurology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- Altered methylation pattern in EXOC4 is associated with stroke outcome: an epigenome-wide association study.Clinical epigenetics · 2022Pooled it
- Biological Age is a predictor of mortality in Ischemic Stroke.Scientific reports · 2018Trial
- Early Dynamics of Body Temperature in Acute Stroke: Insights into Outcomes and Management.Journal of clinical medicine · 2026Article
- Association of A1AT With Poor Functional Outcome in Patients With Acute Ischemic Stroke.Journal of the American Heart Association · 2025Article
- Development of a Risk Tracking Model for Neurological Deterioration in Ischemic Stroke Based on Blood Pressure Dynamics.Journal of the American Heart Association · 2025Article
- Temporal Trends in Stroke Management and Outcomes Between 2011 and 2020 in South Korea: Results From a Nationwide Multicenter Registry.Journal of the American Heart Association · 2025Article
- A predictive model for early neurological deterioration after intravenous thrombolysis in patients with ischemic stroke.Frontiers in neurology · 2025Article
- Pulse pressure level after acute ischemic stroke is associated with early neurological deterioration.Experimental and therapeutic medicine · 2024Article
- Machine Learning Approximations to Predict Epigenetic Age Acceleration in Stroke Patients.International journal of molecular sciences · 2023Article
- Early neurological deterioration in patients with acute ischemic stroke: a prospective multicenter cohort study.Therapeutic advances in neurological disorders · 2023Article
- Epigenetic Clock Explains White Matter Hyperintensity Burden Irrespective of Chronological Age.Biology · 2022Article
- Predictors of Early Neurological Deterioration and Functional Outcome in Acute Ischemic Stroke: The Importance of Large Artery Disease, Hyperglycemia and Inflammatory Blood Biomarkers.Neuropsychiatric disease and treatment · 2022Article
- Article
- Biological age is a novel biomarker to predict stroke recurrence.Journal of neurology · 2021Article
- DNA methylation of MMPs and TIMPs in atherothrombosis process in carotid plaques and blood tissues.Oncotarget · 2020Article
- Association between neurological deterioration and outcomes in patients with stroke.Annals of translational medicine · 2020Article
- Interaction of Sex and Diabetes on Outcome After Ischemic Stroke.Frontiers in neurology · 2018Article
- Early neurological deterioration during the acute phase as a predictor of long-term outcome after first-ever ischemic stroke.Medicine · 2017Observational
- Article
- Complications in the first week after stroke: a 10-year comparison.BMC neurology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the impact that monitored acute stroke unit care may have on the risk of early neurological deterioration (END), and 90-day mortality and mortality-disability.
methodsNon-randomized prospective study with consecutive patients with acute ischemic stroke (AIS) admitted to a conventional care stroke unit (CCSU), from May 2003 to April 2005, or to a monitored acute stroke unit (ASU) from May 2005 to April 2006. END was defined as an increase in the NIHSS score >or= 4 points in the first 72 hours after admission.
resultsEND was detected in 19.6% of patients (11.2% of patients admitted to the ASU and 23.8% to the CCSU; p<0.0001). Patients admitted to the ASU received more treatment with intravenous rtPa (13.5% versus 4.2%; p<0.0001), had a shorter length of stay (9.1 [11.0] d versus 13.1 [10.4] d; p<0.0001), lower 90-day mortality (10.2% versus 17.3%; p=0.02), and lower mortality-disability at 90-days (28.4% versus 40.2%; p=0.004) than those admitted to the CCSU. Multivariable analysis showed that ASU admission was a protector for END (OR: 0.37; 95% CI: 0.23-0.62). On admission, higher NIHSS (OR: 1.06; 95% CI: 1.03-1.10), higher glycaemia (OR: 1.003; 95% CI: 1.001-1.006), and higher systolic pressure (OR: 1.01; 95% CI: 1.002-1.017) were independent predictors of END.
conclusionsEND prevention by ASU care might be a key factor contributing to better outcome and decrease of length of stay in patients admitted to monitored stroke units.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.