ArticleMedical & biological engineering & computing2009
Neuregulin-1 enhances differentiation of cardiomyocytes from embryonic stem cells.
Article in Medical & biological engineering & computing, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 52 citations in OpenAlex.
- Functional prediction of miR-3144-5p in human cardiac myocytes based on transcriptome sequencing and bioinformatics.Medicine · 2017Trial
- Functional impairment of human resident cardiac stem cells by the cardiotoxic antineoplastic agent trastuzumab.Stem cells translational medicine · 2012Trial
- The involvement of Neuregulin-1 in the process of facial nerve injury repair through the utilization of dental pulp stem cells.BMC oral health · 2024Article
- Article
- Neuregulin-1β induces proliferation, survival and paracrine signaling in normal human cardiac ventricular fibroblasts.Journal of molecular and cellular cardiology · 2017Article
- Probing early heart development to instruct stem cell differentiation strategies.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Review
- Neuregulin-1β induces mature ventricular cardiac differentiation from induced pluripotent stem cells contributing to cardiac tissue repair.Stem cells and development · 2015Article
- The roles of neuregulin-1 in cardiac development, homeostasis, and disease.Biomarker insights · 2015Review
- The adult heart responds to increased workload with physiologic hypertrophy, cardiac stem cell activation, and new myocyte formation.European heart journal · 2014Article
- Neuregulin-1β induces embryonic stem cell cardiomyogenesis via ErbB3/ErbB2 receptors.The Biochemical journal · 2014Article
- Time-dependent regulation of neuregulin-1β/ErbB/ERK pathways in cardiac differentiation of mouse embryonic stem cells.Molecular and cellular biochemistry · 2013Article
- Neuregulin in cardiovascular development and disease.Circulation research · 2012Review
- The role of neuregulin/ErbB2/ErbB4 signaling in the heart with special focus on effects on cardiomyocyte proliferation.American journal of physiology. Heart and circulatory physiology · 2012Review
- Improving murine embryonic stem cell differentiation into cardiomyocytes with neuregulin-1: differential expression of microRNA.American journal of physiology. Cell physiology · 2011Article
- Neuregulin/ErbB signaling regulates cardiac subtype specification in differentiating human embryonic stem cells.Circulation research · 2010Article
- Neuregulin signaling and heart failure.Current heart failure reports · 2010Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuregulin-1 (NRG-1) is a multifunctional regulator that acts through receptor tyrosine kinases of the epidermal growth factor (EGF/ErbB) receptor family in diverse tissue. ErbB receptors are expressed in developing embryoid bodies (EBs), and the importance of the NRG-1/ErbB signaling axis in heart development has been investigated, but the underlying molecular mechanism is poorly studied. NRG-1 treatment at 100 ng/ml significantly increased the number of beating EBs of differentiated murine embryonic stem cells (ESCs). Furthermore, NRG-1 up-regulated the expression of the cardiac-restricted transcription factors Nkx2.5 and GATA-4 and factors involved in differentiated cardiac cells (alpha-MHC, beta-MHC and alpha-actinin); NRG-1-induced increase of Nkx2.5 transcription was inhibited by treatment with the PI3 K inhibitor or ErbB receptor inhibitor. Western blot analysis confirmed that the expression of phospho-Akt in the beating foci was increased in the presence of NRG-1. Our results suggest that NRG-1 promotes cardiomyocyte differentiation of ESCs and the ErbB/PI3 K/Akt signaling pathway is one of the underlying molecular mechanisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.