ArticleEuropean journal of nuclear medicine and molecular imaging2009
Uptake of inflammatory cell marker [11C]PK11195 into mouse atherosclerotic plaques.
Article in European journal of nuclear medicine and molecular imaging, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 52 citations in OpenAlex.
- From incidental positron emission uptake toFrontiers in cardiovascular medicine · 2026Review
- Radiopharmaceuticals and their applications in medicine.Signal transduction and targeted therapy · 2025Review
- Targeting the Translocator Protein (18 kDa) in Cardiac Diseases: State of the Art and Future Opportunities.Journal of medicinal chemistry · 2024Review
- PET-Based Imaging withDiagnostics (Basel, Switzerland) · 2021Review
- Molecular Imaging of Vulnerable Coronary Plaque with Radiolabeled Somatostatin Receptors (SSTR).Journal of clinical medicine · 2021Review
- Translocator Protein Modulation by 4'-Chlorodiazepam and NO Synthase Inhibition Affect Cardiac Oxidative Stress, Cardiometabolic and Inflammatory Markers in Isoprenaline-Induced Rat Myocardial Infarction.International journal of molecular sciences · 2021Article
- The Fungal Iron Chelator Desferricoprogen Inhibits Atherosclerotic Plaque Formation.International journal of molecular sciences · 2020Article
- Atherosclerosis Immunoimaging by Positron Emission Tomography.Arteriosclerosis, thrombosis, and vascular biology · 2020Review
- PET imaging of macrophages in cardiovascular diseases.American journal of translational research · 2020Review
- Frontiers in positron emission tomography imaging of the vulnerable atherosclerotic plaque.Cardiovascular research · 2019Review
- Positron Emission Tomography Imaging of Macrophages in Atherosclerosis withContrast media & molecular imaging · 2018Article
- PET imaging of the neurovascular interface in cerebrovascular disease.Nature reviews. Neurology · 2017Review
- 18-kDa translocator protein ligandJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- PET Imaging of Atherosclerotic Disease: Advancing Plaque Assessment from Anatomy to Pathophysiology.Current atherosclerosis reports · 2016Review
- Article
- Recent Advances of Radionuclide-Based Molecular Imaging of Atherosclerosis.Current pharmaceutical design · 2015Review
- Utility of (18) F-FDG and (11)C-PBR28 microPET for the assessment of rat aortic aneurysm inflammation.EJNMMI research · 2014Article
- PET imaging of inflammation in atherosclerosis.Nature reviews. Cardiology · 2014Review
- Biological imaging of atherosclerosis: moving beyond anatomy.Journal of cardiovascular translational research · 2013Review
- Translocator protein (Tspo) gene promoter-driven green fluorescent protein synthesis in transgenic mice: an in vivo model to study Tspo transcription.Cell and tissue research · 2012Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe ligand [(11)C]PK11195 binds with high affinity and selectivity to peripheral benzodiazepine receptor, expressed in high amounts in macrophages. In humans, [(11)C]PK11195 has been used successfully for the in vivo imaging of inflammatory processes of brain tissue. The purpose of this study was to explore the feasibility of [(11)C]PK11195 in imaging inflammation in the atherosclerotic plaques.
methodsThe presence of PK11195 binding sites in the atherosclerotic plaques was verified by examining the in vitro binding of [(3)H]PK11195 onto mouse aortic sections. Uptake of intravenously administered [(11)C]PK11195 was studied ex vivo in excised tissue samples and aortic sections of a LDLR/ApoB48 atherosclerotic mice. Accumulation of the tracer was compared between the atherosclerotic plaques and non-atherosclerotic arterial sites by autoradiography and histological analyses.
resultsThe [(3)H]PK11195 was found to bind to both the atherosclerotic plaques and the healthy wall. The autoradiography analysis revealed that the uptake of [(11)C]PK11195 to inflamed regions in plaques was more prominent (p = 0.011) than to non-inflamed plaque regions, but overall it was not higher than the uptake to the healthy vessel wall. Also, the accumulation of (11)C radioactivity into the aorta of the atherosclerotic mice was not increased compared to the healthy control mice.
conclusionsOur results indicate that the uptake of [(11)C]PK11195 is higher in inflamed atherosclerotic plaques containing a large number of inflammatory cells than in the non-inflamed plaques. However, the tracer uptake to other structures of the artery wall was also prominent and may limit the use of [(11)C]PK11195 in clinical imaging of atherosclerotic plaques.
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