Trial reportIntensive care medicine2008
Physiological effects of noninvasive positive ventilation during acute moderate hypercapnic respiratory insufficiency in children.
Trial report in Intensive care medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Efficacy and Safety of Gastric Feeding in Critically Ill Pediatric Patients Receiving Non-invasive Positive Pressure Ventilation: A Pilot Study
Neurally Adjusted Ventilatory Assist (NAVA) Versus Pressure Support in Pediatric Acute Respiratory Failure - Pilot Study
A Multicentre, Randomized, Clinical Trial of Noninvasive Ventilation: Neurally Adjusted Ventilatory Assist (NAVA) vs. Pressure Support in Pediatric Acute Respiratory Failure - NINAVAPed Protocol
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Clinical Effectiveness of High-Flow Nasal Cannula and Bilevel Positive Airway Pressure in Children with Critical Asthma - A Systematic Review and Meta-Analysis.Indian journal of pediatrics · 2026Pooled it
- Monitoring the patient-ventilator asynchrony during non-invasive ventilation.Frontiers in medicine · 2022Pooled it
- Continuous negative extrathoracic pressure or continuous positive airway pressure compared to conventional ventilation for acute hypoxaemic respiratory failure in children.The Cochrane database of systematic reviews · 2013Pooled it
- Bilevel Positive Airway Pressure and Continuous Albuterol for Pediatric Asthma Exacerbations: A Randomized Clinical Trial.JAMA network open · 2026Trial
- Comparison of the effects of high-flow nasal cannula and bilevel positive airway pressure treatments as respiratory physiotherapy interventions for children with asthma exacerbation: a randomized clinical trial.Einstein (Sao Paulo, Brazil) · 2024Trial
- Helmet Continuous Positive Airway Pressure for Acute Bronchiolitis Respiratory Failure in a Pediatric Ward: Is It a Replicable Experience?Children (Basel, Switzerland) · 2024Article
- Quality Improvement Initiative to Improve Initiation and Acceptability of Noninvasive Ventilation in Critically Ill Children.Indian journal of pediatrics · 2022Article
- A multicentered study on efficiency of noninvasive ventilation procedures (SAFE-NIV)Turkish journal of medical sciences · 2021Observational
- Use of Noninvasive Ventilation and High-Flow NasalSultan Qaboos University medical journal · 2020Review
- Dexmedetomidine is effective and safe during NIV in infants and young children with acute respiratory failure.BMC pediatrics · 2018Article
- Noninvasive Ventilation and High-Flow NasalSultan Qaboos University medical journal · 2018Review
- The top ten unknowns in paediatric mechanical ventilation.Intensive care medicine · 2018Article
- [Noninvasive ventilation in pediatric acute respiratory failure].Notfall & rettungsmedizin · 2017Review
- High flow on the rise-pediatric perspectives on the FLORALI trial.Journal of thoracic disease · 2015Article
- Noninvasive positive pressure ventilation in critically ill children with cardiac disease.Pediatric cardiology · 2014Observational
- Optimal level of nasal continuous positive airway pressure in severe viral bronchiolitis.Intensive care medicine · 2011Article
- Noninvasive positive pressure ventilation for acute respiratory failure in children: a concise review.Annals of intensive care · 2011Article
- Feasibility of non-invasive pressure support ventilation in infants with respiratory failure after extubation: a pilot study.Intensive care medicine · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionA prospective physiological study was performed in 12 paediatric patients with acute moderate hypercapnic respiratory insufficiency to assess the ability of noninvasive positive pressure ventilation (NPPV) to unload the respiratory muscles and improve gas exchange. MATERIALS AND
methodsBreathing pattern, gas exchange, and inspiratory muscle effort were measured during spontaneous breathing and NPPV.
resultsNPPV was associated with a significant improvement in breathing pattern, gas exchange and respiratory muscle output. Tidal volume and minute ventilation increased by 33 and 17%, and oesophageal and diaphragmatic pressure time product decreased by 49 and 56%, respectively. This improvement in alveolar ventilation translated into a reduction in mean partial pressure in carbon dioxide from 48 to 40 mmHg (P = 0.01) and in respiratory rate from 48 to 41 breaths/min (P = 0.01). No difference between a clinical setting and a physiological setting of NPPV was observed. In conclusion, this study shows that NPPV is able to unload the respiratory muscles and improve clinical outcome in young patients admitted to the paediatric intensive care unit for acute moderate hypercapnic respiratory insufficiency.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.