ArticleOncogene2008
Full-length hdmX transcripts decrease following genotoxic stress.
Article in Oncogene, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Quinazoline sulfonamide derivatives targeting MicroRNA-34a/MDM4/p53 apoptotic axis with radiosensitizing activity.Future medicinal chemistry · 2024Article
- Review
- A feedback circuit of miR-34a/MDM4/p53 regulates apoptosis in chronic lymphocytic leukemia cells.Translational cancer research · 2020Article
- MiR-370 promotes apoptosis in colon cancer by directly targeting MDM4.Oncology letters · 2018Article
- Whole genome sequence analysis links chromothripsis to EGFR, MDM2, MDM4, and CDK4 amplification in glioblastoma.Oncoscience · 2015Article
- A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression.Genes & development · 2014Article
- Stress-induced alternative splice forms of MDM2 and MDMX modulate the p53-pathway in distinct ways.PloS one · 2014Article
- MDM2, MDMX and p53 in oncogenesis and cancer therapy.Nature reviews. Cancer · 2013Review
- Genotoxic stress modulates CDC25C phosphatase alternative splicing in human breast cancer cell lines.Molecular oncology · 2012Article
- The emerging functions of the p53-miRNA network in stem cell biology.Cell cycle (Georgetown, Tex.) · 2012Review
- Novel senescence associated gene, YPEL3, is repressed by estrogen in ER+ mammary tumor cells and required for tamoxifen-induced cellular senescence.International journal of cancer · 2012Article
- Article
- Article
- Functions of MDMX in the modulation of the p53-response.Journal of biomedicine & biotechnology · 2011Review
- HDMX-L is expressed from a functional p53-responsive promoter in the first intron of the HDMX gene and participates in an autoregulatory feedback loop to control p53 activity.The Journal of biological chemistry · 2010Article
- HdmX overexpression inhibits oncogene induced cellular senescence.Cell cycle (Georgetown, Tex.) · 2010Article
- YPEL3, a p53-regulated gene that induces cellular senescence.Cancer research · 2010Article
- Role of miR-34c microRNA in the late steps of spermatogenesis.RNA (New York, N.Y.) · 2010Article
- Apoptosis in leukemias: regulation and therapeutic targeting.Cancer treatment and research · 2010Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Previous studies have suggested that the mdmX gene is constitutively transcribed, and that MdmX protein activity is instead controlled by cellular localization and DNA damage induced Mdm2-mediated ubiquitination leading to proteasomal degradation. In these studies, we report that the human mdmX (hdmX) mRNA is reproducibly decreased in various human cell lines following treatment with various DNA-damaging agents. Repression of hdmX transcripts is observed in DNA-damaged HCT116 colon cancer cells and in isogenic p53(-/-) cells, suggesting that this effect is p53-independent. Reduction in the amount of hdmX transcript occurs in both human tumor cell lines and primary human diploid fibroblasts, and results in a significant reduction of HdmX protein. Examination of hdmX promoter activity suggests that damage-induced repression of hdmX mRNA is not significantly impacted by transcription initiation. In contrast, changes in hdmX mRNA splicing appear to partly explain the reduction in full-length hdmX mRNA levels in tumor cell lines with the destabilization of full-length hdmX transcripts, potentially through microRNA miR-34a regulation, also impacting transcript levels. Taken together, this study uncovers previously unrecognized cellular mechanisms by which hdmX mRNA levels are kept low following genotoxic stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.