ArticleProceedings of the National Academy of Sciences of the United States of America1991
The human enhancer-binding protein Gata3 binds to several T-cell receptor regulatory elements.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 104 citations in OpenAlex.
- Characteristics of C4-Type Zinc Finger Proteins in Tardigrades and Their Responses in Extreme Environments.International journal of molecular sciences · 2026Article
- Transcription-dependent spreading of the Dal80 yeast GATA factor across the body of highly expressed genes.PLoS genetics · 2019Article
- A novel loss-of-function mutation of GATA3 (p.R299Q) in a Japanese family with Hypoparathyroidism, Deafness, and Renal Dysplasia (HDR) syndrome.BMC endocrine disorders · 2015Article
- Role and species-specific expression of colon T cell homing receptor GPR15 in colitis.Nature immunology · 2015Article
- From the cradle to the grave: activities of GATA-3 throughout T-cell development and differentiation.Immunological reviews · 2010Review
- Does GATA3 act in tissue-specific pathways? A meta-analysis-based approach.Journal of carcinogenesis · 2008Article
- Preferential transmission and association of the -403 G --> A promoter RANTES polymorphism with atopic asthma.Genes and immunity · 2005Article
- GATA-3 in human T cell helper type 2 development.The Journal of experimental medicine · 2004Article
- TCRalpha enhancer activation occurs via a conformational change of a pre-assembled nucleo-protein complex.The EMBO journal · 2000Article
- Definition of a T-cell receptor beta gene core enhancer of V(D)J recombination by transgenic mapping.Molecular and cellular biology · 2000Article
- Molecular regulation of cytokine gene expression during the immune response.Journal of clinical immunology · 1999Review
- TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3.Molecular and cellular biology · 1998Article
- A conserved sequence block in murine and human T cell receptor (TCR) Jalpha region is a composite element that enhances TCR alpha enhancer activity and binds multiple nuclear factors.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- A conserved tissue-specific structure at a human T-cell receptor beta-chain core promoter.Molecular and cellular biology · 1997Article
- Cross regulation of four GATA factors that control nitrogen catabolic gene expression in Saccharomyces cerevisiae.Journal of bacteriology · 1997Article
- Regulation of T cell receptor delta gene rearrangement by CBF/PEBP2.The Journal of experimental medicine · 1997Article
- Expression of the Runt domain-encoding PEBP2 alpha genes in T cells during thymic development.Molecular and cellular biology · 1995Article
- Elf-1 binds to a critical element in a second CD4 enhancer.Molecular and cellular biology · 1994Article
- GATA elements are necessary for the activity and tissue specificity of the T-cell receptor beta-chain transcriptional enhancer.Molecular and cellular biology · 1994Article
- Identification of a region of a murine leukemia virus long terminal repeat with novel transcriptional regulatory activities.Journal of virology · 1994Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tissue-specific developmental regulation of the alpha, beta, gamma and delta T-cell antigen receptor (TCR) genes is controlled by the corresponding distinct enhancers and their enhancer-binding proteins. To find a common TCR regulatory element, we have studied the ability of the newly described enhancer-binding protein Gata3 to bind to the sequence motif (A/T)GATA(G/A) shared between enhancer elements of all four TCR genes. Gata3 was shown in the chicken to be an enhancer-binding protein containing a zinc-finger domain. We have isolated a full-length human Gata3 cDNA and characterized its role in TCR gene regulation. Northern blot analysis showed that the Gata3 mRNA is present in T-cell, but not B-cell, macrophage or HeLa cell lines. The in vitro transcribed and translated Gata3 cDNA product bound specifically to the enhancer elements of at least three TCR genes containing the above consensus sequence. This binding specificity was consistent with the in vivo activity of the TCR enhancer-binding element in transient transfection assays. Hence, the Gata3 protein, together with other T-cell-specific enhancer-binding proteins, may form the basis of tissue-specific expression of the TCR genes.
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