ArticleProceedings of the National Academy of Sciences of the United States of America1991
Identification and purification of a factor that binds to the Mlu I cell cycle box of yeast DNA replication genes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 53 citations in OpenAlex.
- Genetic instability in budding and fission yeast-sources and mechanisms.FEMS microbiology reviews · 2015Review
- Conformational modulation of DNA by polyamide binding: structural effects of f-Im-Py-Im based derivatives on 5'-ACGCGT-3'.Journal of molecular recognition : JMR · 2013Article
- Affinity and kinetic modulation of polyamide-DNA interactions by N-modification of the heterocycles.Biopolymers · 2013Article
- Checkpoint kinases regulate a global network of transcription factors in response to DNA damage.Cell reports · 2013Article
- Polyamide curvature and DNA sequence selective recognition: use of 4-aminobenzamide to adjust curvature.Medicinal chemistry (Shariqah (United Arab Emirates)) · 2009Article
- Real-time luminescence monitoring of cell-cycle and respiratory oscillations in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Sequence specific and high affinity recognition of 5'-ACGCGT-3' by rationally designed pyrrole-imidazole H-pin polyamides: thermodynamic and structural studies.Bioorganic & medicinal chemistry · 2008Article
- Article
- Human Dbf4/ASK promoter is activated through the Sp1 and MluI cell-cycle box (MCB) transcription elements.Oncogene · 2002Article
- Cell cycle regulation of the tobacco ribonucleotide reductase small subunit gene is mediated by E2F-like elements.The Plant cell · 2000Article
- A computational genomics approach to the identification of gene networks.Nucleic acids research · 1997Article
- Control of S-phase periodic transcription in the fission yeast mitotic cycle.The EMBO journal · 1997Article
- MCB elements and the regulation of DNA replication genes in yeast.Current genetics · 1993Review
- Evidence that POB1, a Saccharomyces cerevisiae protein that binds to DNA polymerase alpha, acts in DNA metabolism in vivo.Molecular and cellular biology · 1992Article
- Regulation of the yeast DNA replication genes through the Mlu I cell cycle box is dependent on SWI6.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Nucleotide sequence and transcriptional regulation of the yeast recombinational repair gene RAD51.Molecular and cellular biology · 1992Article
- Cell cycle control of DNA synthesis in budding yeast.Nucleic acids research · 1992Review
- Control of DNA synthesis genes in budding yeast: involvement of the transcriptional modulator MOT1 in the expression of the DNA polymerase alpha gene.Chromosoma · 1992Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Saccharomyces cerevisiae, the genes encoding at least 10 enzymes involved in DNA replication are periodically expressed in the late G1 and S phases of the cell cycle. All of these genes have one copy or more of the sequence ACGCGT, which conforms to the recognition site for the Mlu I restriction endonuclease. For the CDC21, CDC9, and POL1 genes, the Mlu I site has been shown to be absolutely required for periodic transcription. Using nuclear extracts fractionated by conventional and oligonucleotide affinity chromatography, we have purified a 17-kDa protein that recognizes the Mlu I motif. Synthetic oligonucleotides containing mutated Mlu I sites do not bind the protein. In contrast, synthetic oligonucleotides derived from the CDC2, CDC6, and CDC21 genes, which are expressed with the same timing as POL1, bind purified protein efficiently.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.