ReviewGenetics2008
Tilting at quixotic trait loci (QTL): an evolutionary perspective on genetic causation.
Review in Genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genetic and environmental influences on cannabis use initiation and problematic use: a meta-analysis of twin studies.Addiction (Abingdon, England) · 2010Pooled it
- Interpretable and Predictive Models Based on High-Dimensional Data in Ecology and Evolution.Molecular ecology resources · 2026Article
- Spontaneous single-nucleotide substitutions and microsatellite mutations have distinct distributions of fitness effects.PLoS biology · 2024Article
- Evolutionary psychiatry: foundations, progress and challenges.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023Article
- Disparate genetic variants associated with distinct components of cowpea resistance to the seed beetle Callosobruchus maculatus.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Combining Experimental Evolution and Genomics to Understand How Seed Beetles Adapt to a Marginal Host Plant.Genes · 2020Article
- Genetic Approaches for Sports Performance: How Far Away Are We?Sports medicine (Auckland, N.Z.) · 2019Review
- Inconsistent reproductive isolation revealed by interactions betweenEvolution letters · 2017Article
- Absence of population structure across elevational gradients despite large phenotypic variation in mountain chickadees (Royal Society open science · 2017Article
- What, if anything, are hybrids: enduring truths and challenges associated with population structure and gene flow.Evolutionary applications · 2016Article
- Article
- G72 primate-specific gene: a still enigmatic element in psychiatric disorders.Cellular and molecular life sciences : CMLS · 2016Review
- Sequence- vs. chip-assisted genomic selection: accurate biological information is advised.Genetics, selection, evolution : GSE · 2015Article
- Evolution at two levels of gene expression in yeast.Genome research · 2014Article
- Unraveling genetic origin of aging-related traits: evolving concepts.Rejuvenation research · 2013Review
- The many faces of pleiotropy.Trends in genetics : TIG · 2013Article
- The genetic architecture of a complex ecological trait: host plant use in the specialist moth, Heliothis subflexa.Evolution; international journal of organic evolution · 2012Article
- The changing landscape of genetic testing and its impact on clinical and laboratory services and research in Europe.European journal of human genetics : EJHG · 2012Article
- Dissection of complex adult traits in a mouse synthetic population.Genome research · 2012Article
- Evolution of a membrane protein regulon in Saccharomyces.Molecular biology and evolution · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Recent years have seen great advances in generating and analyzing data to identify the genetic architecture of biological traits. Human disease has understandably received intense research focus, and the genes responsible for most Mendelian diseases have successfully been identified. However, the same advances have shown a consistent if less satisfying pattern, in which complex traits are affected by variation in large numbers of genes, most of which have individually minor or statistically elusive effects, leaving the bulk of genetic etiology unaccounted for. This pattern applies to diverse and unrelated traits, not just disease, in basically all species, and is consistent with evolutionary expectations, raising challenging questions about the best way to approach and understand biological complexity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.