ArticleProceedings of the National Academy of Sciences of the United States of America2008
Exceptional longevity does not result in excessive levels of disability.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
102 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.Aging cell · 2011Pooled it
- Trial
- UCP3 polymorphisms, hand grip performance and survival at old age: association analysis in two Danish middle aged and elderly cohorts.Mechanisms of ageing and development · 2012Trial
- The Tokyo Oldest Old survey on Total Health (TOOTH): a longitudinal cohort study of multidimensional components of health and well-being.BMC geriatrics · 2010Trial
- Emergency trauma admissions in the oldest-old: short- and long-term mortality and the role of frailty in a Turkish national cohort of centenarians.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Functional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants.GeroScience · 2026Article
- Longevity, Centenarians, and Lifestyle: Any ''Tips'' to Live Longer?Current nutrition reports · 2026Review
- The influence of selective mortality on poverty rates in later life: evidence from a Swedish cohort born in 1926.Scandinavian journal of public health · 2025Article
- Health Trajectories of Independent and Dependent Centenarians: A Swedish Nationwide Cohort Study.Innovation in aging · 2025Article
- Unadjusted Lower Limit of Normal for Airflow Obstruction.American journal of respiratory and critical care medicine · 2024Article
- Article
- Dual Functionality in Later Life.The Gerontologist · 2023Article
- Increasing number of long-lived ancestors marks a decade of healthspan extension and healthier metabolomics profiles.Nature communications · 2023Article
- The aging mind: A complex challenge for research and practice.Aging brain · 2023Review
- Age-related macular degeneration and myeloproliferative neoplasms - A common pathway.Acta ophthalmologica · 2022Article
- Loneliness and physical function impairment: Perceived health status as an effect modifier in community-dwelling older adults in Ghana.Preventive medicine reports · 2022Article
- From mutation to mechanism: deciphering the molecular function of genetic variants linked to human ageing.Briefings in functional genomics · 2022Article
- Comparison of Japanese Centenarians' and Noncentenarians' Medical Expenditures in the Last Year of Life.JAMA network open · 2021Article
- Genome-wide association analysis of cognitive function in Danish long-lived individuals.Mechanisms of ageing and development · 2021Article
- Health Trajectories in Swedish Centenarians.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
42 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Late-life loss of independence in daily living is a central concern for the aging individual and for society. The implications of increased survival to advanced age may be different at the population level than at the individual level. Here we used a longitudinal multi-assessment survey of the entire Danish 1905 cohort from 1998 to 2005 to assess the loss of physical and cognitive independence in the age range of 92 to 100 years. Multiple functional outcomes were studied, including independence, which was defined as being able to perform basic activities of daily living without assistance from other persons and having a MiniMental State Examination (MMSE) score of 23 or higher. In the aggregate, the 1905 cohort had only a modest decline in the proportion of independent individuals at the 4 assessments between age 92 and 100 years: 39%, 36%, 32%, and 33%, with a difference between first and last assessment of 6% [95% confidence interval (CI), -1-14%]. For participants who survived until 2005, however, the prevalence of independence was reduced by more than a factor of 2, from 70% in 1998 to 33% in 2005 (difference, 37%; 95% CI, 28-46%). Similar results were obtained for the other functional outcomes. Analyses of missing data resulting from nonresponse and death suggest that the discrepancy between the population trajectory and the individual trajectory is caused by increased mortality among dependent individuals. For the individual, long life brings an increasing risk of loss of independence. For society, mortality reductions are not expected to result in exceptional levels of disability in cohorts of the very old.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.