ArticleMolecular and cellular biology2008
An allelic series uncovers novel roles of the BRCT domain-containing protein PTIP in mouse embryonic vascular development.
Article in Molecular and cellular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- PTIP inhibits proliferation, migration, and angiogenesis of retinal microvascular endothelial cells in a high-glucose environment.In vitro cellular & developmental biology. Animal · 2026Article
- Article
- The genomic stability regulator PTIP is required for proper chromosome segregation in mitosis.Cell division · 2022Article
- PTIP Inhibits Cell Invasion in Esophageal Squamous Cell CarcinomaFrontiers in oncology · 2021Article
- EZH2 variants differentially regulate polycomb repressive complex 2 in histone methylation and cell differentiation.Epigenetics & chromatin · 2018Article
- PTIP promotes recurrence and metastasis of hepatocellular carcinoma by regulating epithelial-mesenchymal transition.Oncotarget · 2017Article
- Article
- Effects of β4 integrin expression on microRNA patterns in breast cancer.Biology open · 2012Article
- High resolution mapping and positional cloning of ENU-induced mutations in the Rw region of mouse chromosome 5.BMC genetics · 2010Article
- PDCD2 is essential for inner cell mass development and embryonic stem cell maintenance.Developmental biology · 2010Article
- Altering a histone H3K4 methylation pathway in glomerular podocytes promotes a chronic disease phenotype.PLoS genetics · 2010Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Pax transactivation domain-interacting protein (PTIP, or PAXIP1) is required for mouse development and has been implicated in DNA damage responses and histone modification. However, the physiological roles of PTIP during embryogenesis remain unclear due to early embryonic lethality of null mutants. We describe two N-ethyl N-nitrosourea-induced hypomorphic missense alleles of Ptip, each of which alters one of the six encoded BRCT domains. Phenotypic characterization of these mutants revealed important functions of PTIP in vasculogenesis and chorioplacental development that appear unrelated to activities in DNA repair or global histone modification. The results of gene expression profiling and in vitro angiogenesis assays indicated that PTIP modulates a transcriptional program, centered around Vegfa, that drives the migration of endothelial cells to properly form the embryonic vasculature. These and other data suggest that PTIP has multiple functions, one of which is to promote the formation of transcriptional complexes that provide specificity of developmental gene expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.