ArticleInfection and immunity2008
Enhanced Toll-like receptor responsiveness associated with mitogen-activated protein kinase activation in Plasmodium falciparum-infected children.
Article in Infection and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The impact of malaria coinfection on Ebola virus disease outcomes: A systematic review and meta-analysis.PloS one · 2021Pooled it
- Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.PLoS pathogens · 2014Trial
- Trial
- The case for exploring innate memory in Plasmodium infection.Current opinion in microbiology · 2026Review
- Controlled Human Malaria Infection Induces Long-Term Functional Changes in Monocytes.Frontiers in molecular biosciences · 2020Article
- Vaccine responses in newborns.Seminars in immunopathology · 2017Review
- Effects of TLR-2/NF-κB signaling pathway on the occurrence of degenerative knee osteoarthritis: an in vivo and in vitro study.Oncotarget · 2017Article
- Article
- Host-pathogen interactions in malaria: cross-kingdom signaling and mitochondrial regulation.Current opinion in immunology · 2015Review
- Factors influencing innate immunity and vaccine responses in infancy.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Innate sensing of malaria parasites.Nature reviews. Immunology · 2014Review
- Interactive transcriptome analysis of malaria patients and infecting Plasmodium falciparum.Genome research · 2014Article
- Parasite virulence, co-infections and cytokine balance in malaria.Pathogens and global health · 2014Review
- Exacerbation of autoimmune neuro-inflammation in mice cured from blood-stage Plasmodium berghei infection.PloS one · 2014Article
- Malaria modifies neonatal and early-life toll-like receptor cytokine responses.Infection and immunity · 2013Article
- Nyctanthes arbor-tristis positively affects immunopathology of malaria-infected mice prolonging its survival.Parasitology research · 2013Article
- Variation between Populations in the Innate Immune Response to Vaccine Adjuvants.Frontiers in immunology · 2013Article
- Toll-like receptor- and filarial antigen-mediated, mitogen-activated protein kinase- and NF-κB-dependent regulation of angiogenic growth factors in filarial lymphatic pathology.Infection and immunity · 2012Article
- Plasmodium yoelii blood-stage primes macrophage-mediated innate immune response through modulation of toll-like receptor signalling.Malaria journal · 2012Article
- Does helminth activation of toll-like receptors modulate immune response in multiple sclerosis patients?Frontiers in cellular and infection microbiology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute Plasmodium falciparum infection is associated with strongly upregulated cytokine responses that are at least partly the result of activation of Toll-like receptors (TLRs). Whether and how TLR expression/responsiveness changes upon malarial infection is, however, currently not well understood. To assess this, we examined expression of TLRs and used the TLR ligand lipopolysaccharide (LPS) and Pam(3)Cys to stimulate peripheral blood mononuclear cells (PBMCs) from Ghanaian schoolchildren who live in a rural area where P. falciparum is endemic. Expression of TLR2 was higher, and responses to its ligand, Pam(3)Cys, were enhanced in P. falciparum-infected children compared to their uninfected counterparts. In cells from the same children, stimulation by Pam(3)Cys resulted in higher p38 mitogen-activated protein kinase activation and higher cytokine production. In vitro experiments confirmed that preincubation of PBMCs with P. falciparum-infected red blood cells enhanced responsiveness to TLR ligands. Taken together, the data indicate that P. falciparum-infected children in areas where malaria is endemic have an altered innate immune system, which might be important for the balance between immunity and pathology when new infections are encountered or when novel vaccines are introduced.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.