ArticleBMC immunology2008
Functional imaging of interleukin 1 beta expression in inflammatory process using bioluminescence imaging in transgenic mice.
Article in BMC immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
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- Anti-inflammatory effects of palm11-PrRP31 in a rat model of lipopolysaccharide-induced acute inflammation.Journal of molecular endocrinology · 2025Article
- Suppression of P2X7R by Local Treatment Alleviates Acute Gouty Inflammation.Journal of inflammation research · 2023Article
- Current and potential roles of immuno-PET/-SPECT in CAR T-cell therapy.Frontiers in medicine · 2023Review
- Bioluminescence imaging of mouse monocyte chemoattractant protein-1 expression in inflammatory processes.Acta biochimica et biophysica Sinica · 2022Article
- Monitoring Immune Cell Function Through Optical Imaging: a Review Highlighting Transgenic Mouse Models.Molecular imaging and biology · 2022Review
- Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer.EMBO molecular medicine · 2022Article
- Compound AD16 Reduces Amyloid Plaque Deposition and Modifies Microglia in a Transgenic Mouse Model of Alzheimer's Disease.ACS pharmacology & translational science · 2020Article
- Transgenic Animal Models to Visualize Cancer-Related Cellular Processes by Bioluminescence Imaging.Frontiers in pharmacology · 2019Review
- Development of In Vivo Imaging Tools for Investigating Astrocyte Activation in Epileptogenesis.Molecular neurobiology · 2018Article
- Inhibition of the P2X7-PANX1 complex suppresses spreading depolarization and neuroinflammation.Brain : a journal of neurology · 2017Article
- Resveratrol mitigates lipopolysaccharide-mediated acute inflammation in rats by inhibiting the TLR4/NF-κBp65/MAPKs signaling cascade.Scientific reports · 2017Article
- Dynamic Changes in the Nigrostriatal Pathway in the MPTP Mouse Model of Parkinson's Disease.Parkinson's disease · 2017Review
- Transgenic mouse model for imaging of interleukin-1β-related inflammation in vivo.Scientific reports · 2015Article
- An integrated pathway interaction network for the combination of four effective compounds from ShengMai preparations in the treatment of cardio-cerebral ischemic diseases.Acta pharmacologica Sinica · 2015Article
- Antibacterial and anti-inflammatory activities of an extract, fractions, and compounds isolated from Gochnatia pulchra aerial parts.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2015Article
- Beneficial effect of butyrate, Lactobacillus casei and L-carnitine combination in preference to each in experimental colitis.World journal of gastroenterology · 2014Article
- Diabetes impairs an interleukin-1β-dependent pathway that enhances neurite outgrowth through JAK/STAT3 modulation of mitochondrial bioenergetics in adult sensory neurons.Molecular brain · 2013Article
- Making the brain glow: in vivo bioluminescence imaging to study neurodegeneration.Molecular neurobiology · 2013Review
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Authors and funding
11 authors.
Funding
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Abstract
backgroundInterleukin 1 beta (IL-1beta) plays an important role in a number of chronic and acute inflammatory diseases. To understand the role of IL-1beta in disease processes and develop an in vivo screening system for anti-inflammatory drugs, a transgenic mouse line was generated which incorporated the transgene firefly luciferase gene driven by a 4.5-kb fragment of the human IL-1beta gene promoter. Luciferase gene expression was monitored in live mice under anesthesia using bioluminescence imaging in a number of inflammatory disease models.
resultsIn a LPS-induced sepsis model, dramatic increase in luciferase activity was observed in the mice. This transgene induction was time dependent and correlated with an increase of endogenous IL-1beta mRNA and pro-IL-1beta protein levels in the mice. In a zymosan-induced arthritis model and an oxazolone-induced skin hypersensitivity reaction model, luciferase expression was locally induced in the zymosan injected knee joint and in the ear with oxazolone application, respectively. Dexamethasone suppressed the expression of luciferase gene both in the acute sepsis model and in the acute arthritis model.
conclusionOur data suggest that the transgenic mice model could be used to study transcriptional regulation of the IL-1beta gene expression in the inflammatory process and evaluation the effect of anti-inflammatory drug in vivo.
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