ArticleBMC medical genomics2008
Tobacco use induces anti-apoptotic, proliferative patterns of gene expression in circulating leukocytes of Caucasian males.
Article in BMC medical genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Clinical Evidence Supports a Protective Role for CXCL5 in Coronary Artery Disease.The American journal of pathology · 2017Article
- Influence of Smoking Status and Intensity on Discovery of Blood Pressure Loci Through Gene-Smoking Interactions.Genetic epidemiology · 2015Article
- Effects of smoking cessation on gene expression in human leukocytes of chronic smoker.Psychiatry investigation · 2014Article
- A gene expression signature from peripheral whole blood for stage I lung adenocarcinoma.Cancer prevention research (Philadelphia, Pa.) · 2011Article
- Cigarette smoke-exposed neutrophils die unconventionally but are rapidly phagocytosed by macrophages.Cell death & disease · 2011Article
- Genetics and beyond--the transcriptome of human monocytes and disease susceptibility.PloS one · 2010Article
- Stable patterns of gene expression regulating carbohydrate metabolism determined by geographic ancestry.PloS one · 2009Article
- Smoking and lung cancer: the role of inflammation.Proceedings of the American Thoracic Society · 2008Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundStrong epidemiologic evidence correlates tobacco use with a variety of serious adverse health effects, but the biological mechanisms that produce these effects remain elusive.
resultsWe analyzed gene transcription data to identify expression spectra related to tobacco use in circulating leukocytes of 67 Caucasian male subjects. Levels of cotinine, a nicotine metabolite, were used as a surrogate marker for tobacco exposure. Significance Analysis of Microarray and Gene Set Analysis identified 109 genes in 16 gene sets whose transcription levels were differentially regulated by nicotine exposure. We subsequently analyzed this gene set by hyperclustering, a technique that allows the data to be clustered by both expression ratio and gene annotation (e.g. Gene Ontologies).
conclusionOur results demonstrate that tobacco use affects transcription of groups of genes that are involved in proliferation and apoptosis in circulating leukocytes. These transcriptional effects include a repertoire of transcriptional changes likely to increase the incidence of neoplasia through an altered expression of genes associated with transcription and signaling, interferon responses and repression of apoptotic pathways.
Identifiers
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Registered trials
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