ArticleBMC research notes2008
Common dietary flavonoids inhibit the growth of the intraerythrocytic malaria parasite.
Article in BMC research notes, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed, 167 citations in OpenAlex.
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- Quercetin as a Promising Antiprotozoan Phytochemical: Current Knowledge and Future Research Avenues.BioMed research international · 2024Review
- Novel Baicalein-Derived Inhibitors ofPathogens (Basel, Switzerland) · 2023Article
- In Silico Studies of Four Compounds ofMolecules (Basel, Switzerland) · 2023Article
- Potent In Vitro and In Vivo Effects ofTropical medicine and infectious disease · 2023Article
- Preclinical evaluation of antimalarial activity of CPF-1 formulation as an alternative choice for the treatment of malaria.BMC complementary medicine and therapies · 2023Article
- Nutritional Composition and Antioxidant Activity ofPlants (Basel, Switzerland) · 2023Article
- Anti-Toxoplasma Activities of Some Egyptian Plant Extracts: An In Vitro Study.Acta parasitologica · 2022Article
- Exploring Potential Antimalarial Candidate from Medicinal Plants of Kheaw Hom Remedy.Tropical medicine and infectious disease · 2022Article
- Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFlavonoids are abundant plant phenolic compounds. More than 6000 have been identified to date, and some have been shown to possess antiparasitic activity. Here we investigate the effects of a range of common dietary flavonoids on the growth of two strains of the human malaria parasite Plasmodium falciparum.
findingsA chloroquine-sensitive (3D7) and a chloroquine-resistant (7G8) strain of P. falciparum were tested for in vitro susceptibility to a range of individual dietary flavonoids and flavonoid combinations. Parasite susceptibility was measured in 96-well plates over 96 h using a previously described [3H]hypoxanthine incorporation assay. Of the eleven flavonoids tested, eight showed antiplasmodial activity against the 3D7 strain (with IC50 values between 11 and 66 muM), and all showed activity against the 7G8 strain (with IC50 values between 12 and 76 muM). The most active compound against both strains was luteolin, with IC50 values of 11 +/- 1 muM and 12 +/- 1 muM for 3D7 and 7G8, respectively. Luteolin was found to prevent the progression of parasite growth beyond the young trophozoite stage, and did not affect parasite susceptibility to the antimalarial drugs chloroquine or artemisinin. Combining low concentrations of flavonoids was found to produce an apparent additive antiplasmodial effect.
conclusionCertain common dietary flavonoids inhibit the intraerythrocytic growth of the 3D7 and 7G8 strains of P. falciparum. Flavonoid combinations warrant further investigation as antiplasmodial agents.
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Registered trials
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