ArticleBrain pathology (Zurich, Switzerland)2009
Interphase cytogenetics for 1p19q and t(1;19)(q10;p10) may distinguish prognostically relevant subgroups in extraventricular neurocytoma.
Article in Brain pathology (Zurich, Switzerland), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 58 citations in OpenAlex.
- Neurocytomas: long-term experience of a single institution.Neuro-oncology · 2011Trial
- Radiomic features from dynamic susceptibility contrast perfusion-weighted imaging improve the three-class prediction of molecular subtypes in patients with adult diffuse gliomas.European radiology · 2023Article
- A rare case of atypical spinal neurocytoma with EGFR mutation in a 12-year-old boy.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Pineal Gland Tumors: A Review.Cancers · 2021Review
- Use of Fluorescence In Situ Hybridization (FISH) in Diagnosis and Tailored Therapies in Solid Tumors.Molecules (Basel, Switzerland) · 2020Review
- Cerebellar Liponeurocytoma: Relevant Clinical Cytogenetic Findings.Journal of pathology and translational medicine · 2017Article
- A comparative study of intraventricular central neurocytomas and extraventricular neurocytomas.Journal of neuro-oncology · 2015Article
- Differential hypermethylation of death-associated protein kinase promoter in central neurocytoma and oligodendroglioma.BioMed research international · 2014Article
- Extraventricular neurocytoma in pediatric populations: A case report and review of the literature.Oncology letters · 2013Article
- Chromogenic in situ hybridization is a reliable alternative to fluorescence in situ hybridization for diagnostic testing of 1p and 19q loss in paraffin-embedded gliomas.Brain pathology (Zurich, Switzerland) · 2013Article
- Pathologic features and clinical outcome of central neurocytoma: analysis of 15 cases.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2012Article
- A rare case of a pediatric extraventricular neurocytoma: case report and review of the literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2012Review
- Gamma knife radiosurgery for cranial neurocytomas.Journal of neuro-oncology · 2011Article
- Gone FISHing: clinical lessons learned in brain tumor molecular diagnostics over the last decade.Brain pathology (Zurich, Switzerland) · 2011Review
- Re: Diffuse leptomeningeal glioneuronal tumors: a new entity?Brain pathology (Zurich, Switzerland) · 2009Article
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9 authors at 3 institutions in 1 country.
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Abstract
Co-deletion of chromosome arms 1p and 19q, characteristic of oligodendroglial tumors, was recently found to be mediated by t(1;19)(q10;p10). To evaluate the prevalence of 1p19q co-deletion and t(1;19) in extraventricular neurocytomas (EVN), we studied tumors from 23 patients, including 13 females and 10 males (median age at diagnosis 34 years, range 2-76 years). Fluorescence in situ hybridization (FISH) studies were performed with probes targeting 1p36/1q25 and 19q13/19p13 to assess for 1p19q co-deletion, as well as chromosome 1 alpha-satellite and 19p12 to detect t(1;19)(q10;p10). FISH was successful in 21 (91%) cases and demonstrated 1p19q co-deletion in five cases (24%) or isolated 1p loss in two cases (10%). Evidence for t(1;19) was found in four (of five) cases with 1p19q co-deletion. Three tumors with 1p19q loss and t(1;19) demonstrated atypical histologic features, compared with one (of 17) tumors without 1p19q co-deletion (P = 0.01, Fisher exact test). In addition, tumors with t(1;19) showed increased mitotic activity compared with tumors without t(1;19) (P = 0.045; Wilcoxon rank sum test). The four patients with t(1;19) developed tumor recurrence (n = 3), or expired (n = 2) 3.5 to 5.5 years after first resection. These results suggest that 1p19q loss and t(1;19) occur in a subset of EVN, and may be associated with aggressive histology in these tumors.
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