ArticleMovement disorders : official journal of the Movement Disorder Society2008
Cancer and blood concentrations of the comutagen harmane in essential tremor.
Article in Movement disorders : official journal of the Movement Disorder Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Integration of the Microbiome, Metabolome and Transcriptomics Data Identified Novel Metabolic Pathway Regulation in Colorectal Cancer.International journal of molecular sciences · 2021Article
- Conditions Associated with Essential Tremor in Veterans: A Potential Role for Chronic Stress.Tremor and other hyperkinetic movements (New York, N.Y.) · 2018Article
- Increased Odds of Melanoma: Parkinson's Disease, Essential Tremor, Dystonia versus Controls.Neuroepidemiology · 2016Article
- Frailty in elderly persons with essential tremor: a population-based study (NEDICES).European journal of neurology · 2011Article
- Beta-carboline alkaloids and essential tremor: exploring the environmental determinants of one of the most prevalent neurological diseases.TheScientificWorldJournal · 2010Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Blood concentrations of harmane, a tremor-producing neurotoxin, are elevated in essential tremor (ET). Harmane is also a comutagen. Using a case-control design, we compared the prevalence of cancer in ET cases vs. controls, and determined whether blood harmane concentrations are elevated among ET cases with cancer. 66/267 (24.7%) ET cases vs. 55/331 (16.6%) controls had cancer (adjusted OR 1.52, 95% CI 1.01-2.30, P = 0.04). Among specific cancer types, colon cancer was more prevalent in ET cases than controls (2.6% vs. 0.6%, P = 0.04). Log blood harmane concentration was higher in ET cases vs. controls (P = 0.02) and in participants with vs. without cancer (P = 0.02). Log blood harmane concentration was highest in ET cases with cancer when compared with other groups (P = 0.009). These links between cancer and ET and between high blood harmane and cancer in ET deserve further study.
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