ArticleGlia2009
Mitogen-activated protein kinase-signaling stimulates Müller glia to proliferate in acutely damaged chicken retina.
Article in Glia, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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Who cites it
72 citing papers in PubMed, 110 citations in OpenAlex.
- RNA interference to reduceMolecular vision · 2026Article
- The neuroimmune interface in retinal regeneration.Progress in retinal and eye research · 2025Review
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- Article
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- Protein phosphatases regulate the formation of Müller glia-derived progenitor cells in the chick retina.Molecular and cellular neurosciences · 2024Article
- Comparison of the effects of EGF, FGF-b, and NGF on the proliferation, migration, and reprogramming of primary rat Müller cells.Frontiers in cellular neuroscience · 2024Article
- Protein phosphatases regulate the formation of Müller glia-derived progenitor cells in the chick retina.bioRxiv : the preprint server for biology · 2023Article
- Heparin-binding epidermal growth factor and fibroblast growth factor 2 rescue Müller glia-derived progenitor cell formation in microglia- and macrophage-ablated chick retinas.Development (Cambridge, England) · 2023Article
- Chromatin access regulates the formation of Müller glia-derived progenitor cells in the retina.Glia · 2023Article
- Review
- Patterns of NFkB activation resulting from damage, reactive microglia, cytokines, and growth factors in the mouse retina.Experimental neurology · 2023Article
- Modification of Müller Glial Cell Fate and Proliferation with the Use of Small Molecules.Advances in experimental medicine and biology · 2023Review
- Fatty acid-binding proteins and fatty acid synthase influence glial reactivity and promote the formation of Müller glia-derived progenitor cells in the chick retina.Development (Cambridge, England) · 2022Article
- Retina regeneration: lessons from vertebrates.Oxford open neuroscience · 2022Review
- Inhibiting the activation of MAPK (ERK1/2) in stressed Müller cells prevents photoreceptor degeneration.Theranostics · 2022Article
- Jack of all trades, master of each: the diversity of fibroblast growth factor signalling in eye development.Open biology · 2022Review
- Review
- Article
- Müller Glia-Mediated Retinal Regeneration.Molecular neurobiology · 2021Review
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Müller glia in the mature retina have the capacity to become progenitor-like cells in a many different vertebrate classes. The cell-signaling pathways that control the ability of mature Müller glia to become progenitor-like cells remain uncertain. The purpose of this study was to investigate the roles of the Mitogen-Activated Protein Kinase (MAPK) pathway in regulating the activity of Müller glia in the chicken retina. In response to acute retinal damage, we found that Müller glia accumulated phosphorylated ERK1/2 and phospho-CyclicAMP Response Element Binding-protein (pCREB), and transiently expressed immediate early genes, cFos and Egr1, that are known to be downstream of MAPK-signaling. Egr1 and pCREB were normally expressed by retinal progenitors in the circumferential marginal zone (CMZ), whereas cFos and pERK1/2 were not. In addition, small molecule inhibitors of MEK (UO126) and the FGF-receptor (SU5402) suppressed the proliferation of Müller glia-derived progenitor-like cells. These inhibitors suppressed the accumulation of Egr1 and pCREB, whereas levels of cFos were unaffected in the glial cells. These findings suggest that Egr1 and pCREB are downstream of the signaling cascade activated by FGF-receptors and ERK1/2. Further, our findings suggest that Egr1 and pCREB may promote glial proliferation. We propose that activation of both the FGF-receptor and ERK1/2-pathway is required for the proliferation and transdifferentiation of Müller glia into progenitor-like cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.