ArticleDigestive diseases and sciences2009
Re-evaluation of histogenesis of gastric carcinomas: a comparative histopathological study between Helicobacter pylori-negative and H. pylori-positive cases.
Article in Digestive diseases and sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 64 citations in OpenAlex.
- ADMA mediates gastric cancer cell migration and invasion via Wnt/β-catenin signaling pathway.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2021Trial
- Gastric neoplasm with foveolar-cell differentiation inHistology and histopathology · 2026Review
- <italic>Helicobacter pylori</italic>-Naïve Gastric Neoplasms: Clinicopathological and Molecular Features and Diagnostic Challenges.Digestion · 2026Review
- Apoptosis induction and inhibition of invasion and migration in gastric cancer cells by Isoorientin studied using network pharmacology.BMC complementary medicine and therapies · 2024Article
- Verrucous gastritis-like lesion in intramucosal Helicobacter pylori-uninfected signet ring cell carcinoma with poorly differentiated adenocarcinoma.Clinical journal of gastroenterology · 2024Article
- Trends of EarlyJournal of clinical medicine · 2024Article
- Article
- Gastric Foveolar-type Adenocarcinoma with Raspberry-like Appearance in a Helicobacter pylori-uninfected Stomach: A Long-term Retrospective Follow-up of 16 Years.Internal medicine (Tokyo, Japan) · 2023Article
- [Clinicopathological features ofBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023Article
- Differences in Regression Patterns of Complete and Incomplete Intestinal Metaplasia at Ten Years afterActa histochemica et cytochemica · 2021Article
- Evaluating the presence of Mycoplasma hyorhinis, Fusobacterium nucleatum, and Helicobacter pylori in biopsies of patients with gastric cancer.Infectious agents and cancer · 2021Article
- Endoscopic and histological features ofJGH open : an open access journal of gastroenterology and hepatology · 2021Article
- A rare case of Helicobacter pylori-uninfected intramucosal poorly differentiated adenocarcinoma that occurred in the gastric fornix.Clinical journal of gastroenterology · 2021Article
- Incidence and prognosis of undifferentiated cancers of the digestive system: a population-based cohort study.Annals of translational medicine · 2021Article
- Clinicopathological features of early gastric cancers arising inWorld journal of gastroenterology · 2020Article
- Gastric adenocarcinoma coexisting with a reddish semipedunculated polyp arising from Helicobacter pylori-negative normal gastric mucosa: a report of two cases.Clinical journal of gastroenterology · 2018Article
- Guilt by association: intestinal metaplasia does not progress to gastric cancer.Current opinion in gastroenterology · 2018Review
- Serum pepsinogen levels indicate the requirement of upper gastrointestinal endoscopy among Group A subjects of ABC classification: a multicenter study.Journal of gastroenterology · 2018Article
- Plasticity of differentiated cells in wound repair and tumorigenesis, part I: stomach and pancreas.Disease models & mechanisms · 2018Review
- Helicobacter pylori-negative gastric cancer: advanced-stage undifferentiated adenocarcinoma located in the pyloric gland area.Clinical journal of gastroenterology · 2017Article
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7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
We histopathologically re-evaluated the histogenesis of gastric carcinomas from comparative studies between Helicobacter pylori-positive and H. pylori-negative cases using the gastritis score from the Updated Sydney System. The incidence of H. pylori-negative gastric carcinomas was 3.11% (12/386); they are likely to develop in the fundic gland mucosa, and show a gastric phenotype by mucin immunohistochemistry. Even in cases of completely gastric and predominantly gastric phenotypes, CDX2 protein was expressed in most cases (90.9% of pT1 and 100% of pT2-3), indicating a possibility that intestinalization of carcinoma cells occurs independently of the background mucosa. Regarding the degree of gastritis of background mucosa surrounding 143 H. pylori-positive differentiated-type adenocarcinomas, the mean score ranged from 1.497 to 1.713. Our data support the hypothesis that intestinal metaplasia is not a precancerous but a paracancerous lesion, and most gastric adenocarcinomas develop in mildly to moderately atrophic mucosa with H. pylori-infection, i.e., ongoing atrophy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.